(R)-3-benzyl-4-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)oxazolidin-2-one

Base Information

Chemical Name:(R)-3-benzyl-4-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)oxazolidin-2-one
CAS No.:1234550-85-6
Molecular Formula:C₂₀H₂₁NO₆
Molecular Weight:371.39
Hs Code.:

Synonyms:(R)-3-benzyl-4-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)oxazolidin-2-one

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Chemical Property of (R)-3-benzyl-4-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)oxazolidin-2-one

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Technology Process of (R)-3-benzyl-4-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)oxazolidin-2-one

There total 3 articles about (R)-3-benzyl-4-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1234550-84-5
(R)-tert-butyl 2-hydroxy-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethylcarbamate

: 100-39-0
benzyl bromide

: 1234550-85-6
(R)-3-benzyl-4-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)oxazolidin-2-one

: 1234550-76-5
(R)-tert-butyl 2-(benzyloxy)-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethylcarbamate

Guidance literature:: (R)-tert-butyl 2-hydroxy-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethylcarbamate; With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.666667h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil; regioselective reaction;
DOI:10.1021/jo100788j

Reference yield:

: C₂₉H₃₇NO₄Si

: 1234550-85-6
(R)-3-benzyl-4-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)oxazolidin-2-one

: 1234550-76-5
(R)-tert-butyl 2-(benzyloxy)-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 °C / Inert atmosphere

3.2: 1 h / 0 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo100788j

Reference yield:

: C₃₄H₄₅NO₆Si

: 1234550-85-6
(R)-3-benzyl-4-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)oxazolidin-2-one

: 1234550-76-5
(R)-tert-butyl 2-(benzyloxy)-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo100788j