(R)-tert-butyl 2-(benzyloxy)-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethylcarbamate

Base Information

• Chemical Name: (R)-tert-butyl 2-(benzyloxy)-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethylcarbamate
• CAS No.: 1234550-76-5
• Molecular Formula: C₂₄H₃₁NO₇
• Molecular Weight: 445.513

Synonyms:(R)-tert-butyl 2-(benzyloxy)-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethylcarbamate

Chemical Property of (R)-tert-butyl 2-(benzyloxy)-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl 2-(benzyloxy)-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethylcarbamate

There total 4 articles about (R)-tert-butyl 2-(benzyloxy)-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(R)-tert-butyl 2-hydroxy-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethylcarbamate (1234550-84-5) + benzyl bromide (100-39-0) → (R)-3-benzyl-4-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)oxazolidin-2-one (1234550-85-6) + (R)-tert-butyl 2-(benzyloxy)-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethylcarbamate (1234550-76-5)

Guidance literature:

(R)-tert-butyl 2-hydroxy-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethylcarbamate; With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.666667h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil; regioselective reaction;

DOI:10.1021/jo100788j

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (R)-tert-butyl 2-(benzyloxy)-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethylcarbamate (1234550-76-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 °C / Inert atmosphere

3.2: 1 h / 0 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/jo100788j

Reference yield:

C29H37NO4Si → (R)-3-benzyl-4-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)oxazolidin-2-one (1234550-85-6) + (R)-tert-butyl 2-(benzyloxy)-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethylcarbamate (1234550-76-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 °C / Inert atmosphere

3.2: 1 h / 0 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/jo100788j

upstream raw materials:

(R)-tert-butyl 2-hydroxy-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethylcarbamate

benzyl bromide

di-tert-butyl dicarbonate

Downstream raw materials:

(R)-7-(1-amino-2-(benzyloxy)ethyl)-4-methylbenzo[d][1,3]dioxol-5-yl methanesulfonate

7-((4R,7S)-7-(2-bromo-5-hydroxy-4-methoxy-3-methylbenzyl)-12,12,12-trichloro-6,9-dioxo-8-(2-oxopropyl)-1-phenyl-2,10-dioxa-5,8-diazadodecan-4-yl)-4-methylbenzo[d][1,3]dioxol-5-yl methanesulfonate

(S)-2,2,2-trichloroethyl 4-((R)-2-(benzyloxy)-1-(7-methyl-6-(methylsulfonyloxy)benzo[d][1,3]dioxol-4-yl)ethyl)-2-(2-bromo-5-hydroxy-4-methoxy-3-methylbenzyl)-5-methyl-3-oxo-3,4-dihydropyrazine-1(2H)-carboxylate

C₃₅H₃₄BrCl₃N₂O₁₁S

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