(1R,3S,4S)-2-Boc-2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid Methyl ester

Base Information

• Chemical Name: (1R,3S,4S)-2-Boc-2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid Methyl ester
• CAS No.: 1181573-36-3
• Molecular Formula: C₁₃H₂₁NO₄
• Molecular Weight: 255.314
• Mol file: 1181573-36-3.mol

Synonyms:(1R,3S,4S)-2-azabicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester 3-methyl ester

Chemical Property of (1R,3S,4S)-2-Boc-2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid Methyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(1R,3S,4R)-2-Boc-2-aza-bicyclo[2.2.1]heptane-3-carboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

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MSDS Files:

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Technology Process of (1R,3S,4S)-2-Boc-2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid Methyl ester

There total 5 articles about (1R,3S,4S)-2-Boc-2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(1R,3S,4S)-2-aza-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester (134795-25-8,291775-59-2,134877-63-7) + methyl iodide (74-88-4) → (1R,3S,4S)-2-azabicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester 3-methyl ester (1181573-36-3)

Guidance literature:

With potassium acetate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 77.3%

di-tert-butyl dicarbonate (24424-99-5) + (1R,3S,4S)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid methyl ester (220093-41-4) → (1R,3S,4S)-2-azabicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester 3-methyl ester (1181573-36-3)

Guidance literature:

With sodium carbonate; In methanol; water; for 0.5h; pH=8; Inert atmosphere;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (1S,3S,4R)-2-[(1R)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid methyl ester (130194-96-6) → (1R,3S,4S)-2-azabicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester 3-methyl ester (1181573-36-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 5250.53 Torr;

upstream raw materials:

di-tert-butyl dicarbonate

(1S,3S,4R)-2-[(1R)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid methyl ester

(1R,3S,4S)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid methyl ester

(1R,3S,4S)-2-aza-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester

Downstream raw materials:

methyl ((S)-1-((1R,3S,4S)-3-(5-(4-bromophenyl)-1H-imidazol-2-yl)-2-azabicyclo[2.2.1]heptan-2-yl)-3-methyl-1-oxobutan-2-yl)carbamate

(1R,3S,4S)-tert-butyl 3-(6-(4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1Himidazol-5-yl)biphenyl-4-yl)-1H-benzo[d]imidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate

3-(2-amino-4-bromo-phenylcarbamoyl)-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

(1R,3S,4S)-2-aza-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester

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