4-(2-chlorophenyl)-9-methyl-2[(trimethylsilyl)ethynyl]-6H-thieno[3,2-f][1,2,4]triazolo [4,3-a][1,4]diazepine

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Chemical Name:4-(2-chlorophenyl)-9-methyl-2[(trimethylsilyl)ethynyl]-6H-thieno[3,2-f][1,2,4]triazolo [4,3-a][1,4]diazepine
CAS No.:125030-59-3
Molecular Formula:C₂₀H₁₉ClN₄SSi
Molecular Weight:411.002
Hs Code.:

Synonyms:4-(2-chlorophenyl)-9-methyl-2[(trimethylsilyl)ethynyl]-6H-thieno[3,2-f][1,2,4]triazolo [4,3-a][1,4]diazepine

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Chemical Property of 4-(2-chlorophenyl)-9-methyl-2[(trimethylsilyl)ethynyl]-6H-thieno[3,2-f][1,2,4]triazolo [4,3-a][1,4]diazepine

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Technology Process of 4-(2-chlorophenyl)-9-methyl-2[(trimethylsilyl)ethynyl]-6H-thieno[3,2-f][1,2,4]triazolo [4,3-a][1,4]diazepine

There total 1 articles about 4-(2-chlorophenyl)-9-methyl-2[(trimethylsilyl)ethynyl]-6H-thieno[3,2-f][1,2,4]triazolo [4,3-a][1,4]diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 67860-41-7
4-(2-chlorophenyl)2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

: 1066-54-2
trimethylsilylacetylene

: 125030-59-3
4-(2-chlorophenyl)-9-methyl-2[(trimethylsilyl)ethynyl]-6H-thieno[3,2-f][1,2,4]triazolo [4,3-a][1,4]diazepine

Guidance literature:: With copper(l) iodide; palladium diacetate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; for 4h; Ambient temperature;
DOI:10.1021/jm00108a031

Reference yield: 82.0%

: 125030-59-3
4-(2-chlorophenyl)-9-methyl-2[(trimethylsilyl)ethynyl]-6H-thieno[3,2-f][1,2,4]triazolo [4,3-a][1,4]diazepine

: 125031-31-4
4-(2-Chlorophenyl)-2-ethynyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo [4,3-a][1,4]diazepine

Guidance literature:: With sodium hydroxide; In ethanol; for 0.25h; Ambient temperature;
DOI:10.1021/jm00108a031

Reference yield:

: 125030-59-3
4-(2-chlorophenyl)-9-methyl-2[(trimethylsilyl)ethynyl]-6H-thieno[3,2-f][1,2,4]triazolo [4,3-a][1,4]diazepine

: 132464-78-9
4-(2-Chloro-phenyl)-2-[2-(4-imidazol-1-yl-phenyl)-ethyl]-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / 2 N NaOH / ethanol / 0.25 h / Ambient temperature

2: Ph₃P, CuI, Et₃N, palladium acetate / dimethylformamide / 2 h / Ambient temperature

3: H₂ / 5percent Pd/C / ethanol; tetrahydrofuran / 5 h / 760 Torr

With sodium hydroxide; copper(l) iodide; hydrogen; palladium diacetate; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00108a031