4-(2-Chloro-phenyl)-2-[2-(4-imidazol-1-yl-phenyl)-ethyl]-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene

Base Information

Chemical Name:4-(2-Chloro-phenyl)-2-[2-(4-imidazol-1-yl-phenyl)-ethyl]-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene
CAS No.:132464-78-9
Molecular Formula:C₂₆H₂₁ClN₆S
Molecular Weight:485.012
Hs Code.:

Synonyms:4-(2-Chloro-phenyl)-2-[2-(4-imidazol-1-yl-phenyl)-ethyl]-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene

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Chemical Property of 4-(2-Chloro-phenyl)-2-[2-(4-imidazol-1-yl-phenyl)-ethyl]-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene

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Technology Process of 4-(2-Chloro-phenyl)-2-[2-(4-imidazol-1-yl-phenyl)-ethyl]-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene

There total 6 articles about 4-(2-Chloro-phenyl)-2-[2-(4-imidazol-1-yl-phenyl)-ethyl]-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(2-Chloro-phenyl)-2-(4-imidazol-1-yl-phenylethynyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene

: 132464-78-9
4-(2-Chloro-phenyl)-2-[2-(4-imidazol-1-yl-phenyl)-ethyl]-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; for 5h; under 760 Torr; Yield given;
DOI:10.1021/jm00108a031

Reference yield:

: 67860-41-7
4-(2-chlorophenyl)2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

: 132464-78-9
4-(2-Chloro-phenyl)-2-[2-(4-imidazol-1-yl-phenyl)-ethyl]-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / CuI, Ph₃P, Et₃N, palladium acetate / dimethylformamide / 4 h / Ambient temperature

2: 82 percent / 2 N NaOH / ethanol / 0.25 h / Ambient temperature

3: Ph₃P, CuI, Et₃N, palladium acetate / dimethylformamide / 2 h / Ambient temperature

4: H₂ / 5percent Pd/C / ethanol; tetrahydrofuran / 5 h / 760 Torr

With sodium hydroxide; copper(l) iodide; hydrogen; palladium diacetate; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00108a031

Reference yield:

: 132464-89-2
1-(4-iodo-phenyl)-1H-imidazole

: 132464-78-9
4-(2-Chloro-phenyl)-2-[2-(4-imidazol-1-yl-phenyl)-ethyl]-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene

Guidance literature:: Multi-step reaction with 2 steps

1: Ph₃P, CuI, Et₃N, palladium acetate / dimethylformamide / 2 h / Ambient temperature

2: H₂ / 5percent Pd/C / ethanol; tetrahydrofuran / 5 h / 760 Torr

With copper(l) iodide; hydrogen; palladium diacetate; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00108a031