5-Nitro-6-methylaminoquinoline

Base Information

• Chemical Name: 5-Nitro-6-methylaminoquinoline
• CAS No.: 14204-97-8
• Molecular Formula: C₁₀H₉N₃O₂
• Molecular Weight: 203.2
• Hs Code.: 2933499090
• Mol file: 14204-97-8.mol

Synonyms:Quinoline,6-(methylamino)-5-nitro- (8CI); 6-(Methylamino)-5-nitroquinoline; NSC 639644

Chemical Property of 5-Nitro-6-methylaminoquinoline

Chemical Property:

• Vapor Pressure: 2.33E-06mmHg at 25°C
• Melting Point: 188-190°C; 130°C soft.
• Refractive Index: 1.717
• Boiling Point: 392.2°C at 760 mmHg
• Flash Point: 191°C
• PSA: 70.74000
• Density: 1.372g/cm³
• LogP: 2.78090
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-Nitro-6-methylaminoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Nitro-6-methylaminoquinoline (cas# 14204-97-8) is a compound useful in organic synthesis.

Technology Process of 5-Nitro-6-methylaminoquinoline

There total 9 articles about 5-Nitro-6-methylaminoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

6-bromo-5-nitroquinoline (98203-04-4) + methylamine (74-89-5) → 6-methylamino-5-nitroquinoline (14204-97-8)

Guidance literature:

In ethanol; for 70h; Ambient temperature;

Reference yield: 86.0%

6-methoxy-5-nitroquinoline (6623-91-2) + methylamine (74-89-5) → 6-methylamino-5-nitroquinoline (14204-97-8)

Guidance literature:

In ethanol; for 5h; Heating;

Reference yield: 81.0%

N-methylquinolin-6-amine (83407-38-9) → 6-methylamino-5-nitroquinoline (14204-97-8)

Guidance literature:

With nitronium ion;

DOI:10.1248/cpb.29.590

upstream raw materials:

N-methylquinolin-6-amine

5-nitroquinoline

methylamine

6-bromo-5-nitroquinoline

Downstream raw materials:

5-amino-6-methylaminoquinoline

2-Amino-3-methylimidazo[4,5-f]quinoline

Refernces

• 1、 Ronne, Erik,Grivas, Spiros,Olsson, Kjell. "Synthetic Routes to the Carcinogen IQ and Related 3H-Imidazoquinolines". . p. 823 - 830. Retrieved 2007/10/02.
• 2、 Bashir, Mohammad,Kingston, David G. I.,Carman, Robert J.,Tassell, Roger L. van,Wilkins, Tracy D.. "BIOLOGICAL FORMATION AND CHEMICAL SYNTHESIS OF 2-AMINO-3,6-DIHYDRO-3-METHYL-7H-IMIDAZOLOQUINOLIN-7-ONE, THE MAJOR METABOLITE OF THE DIETARY CARCINOGEN 2-AMINO-3-METHYL-3H-IMIDAZOLOQUINOLINE (IQ) BY NORMAL INTESTINAL BACTERIA". . p. 2877 - 2886. Retrieved 2007/10/02.