ethyl 3-(((6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)amino)methyl)benzoate

Base Information

Chemical Name:ethyl 3-(((6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)amino)methyl)benzoate
CAS No.:1351957-41-9
Molecular Formula:C₂₆H₃₁N₅O₂S
Molecular Weight:477.63
Hs Code.:

Synonyms:ethyl 3-(((6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)amino)methyl)benzoate

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Chemical Property of ethyl 3-(((6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)amino)methyl)benzoate

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Technology Process of ethyl 3-(((6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)amino)methyl)benzoate

There total 8 articles about ethyl 3-(((6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)amino)methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-17-5
ethanol

: 1351956-54-1
6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-amine

: 1571-08-0
methyl 4-formylbenzoate

: 1351957-41-9
ethyl 3-(((6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)amino)methyl)benzoate

Guidance literature:: 6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-amine; methyl 4-formylbenzoate; In toluene; at 100 ℃; Molecular sieve; Sealed tube;

ethanol; With sodium tetrahydroborate; In toluene; at 60 - 100 ℃; for 40h;

Reference yield:

: 13211-00-2
N-(4-butyrylphenyl)acetamide

: 1351957-41-9
ethyl 3-(((6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)amino)methyl)benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: aluminum (III) chloride; bromine / dichloromethane / 3.5 h / 0 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / chloroform; methanol / 48 h / 20 °C

3.1: sodium tetrahydroborate; methanol / 20 °C / Inert atmosphere; Cooling with ice

4.1: acetonitrile / Reflux

5.1: hydrogenchloride / water / 60 °C

6.1: bromine; acetic acid / 1 h / 7 - 20 °C

7.1: toluene / 100 °C / Molecular sieve; Sealed tube

7.2: 40 h / 60 - 100 °C

With hydrogenchloride; methanol; aluminum (III) chloride; sodium tetrahydroborate; bromine; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; chloroform; water; toluene; acetonitrile;

Reference yield:

: 1310320-05-8
N-(4-(2-bromobutanoyl)phenyl)acetamide

: 1351957-41-9
ethyl 3-(((6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)amino)methyl)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / chloroform; methanol / 48 h / 20 °C

2.1: sodium tetrahydroborate; methanol / 20 °C / Inert atmosphere; Cooling with ice

3.1: acetonitrile / Reflux

4.1: hydrogenchloride / water / 60 °C

5.1: bromine; acetic acid / 1 h / 7 - 20 °C

6.1: toluene / 100 °C / Molecular sieve; Sealed tube

6.2: 40 h / 60 - 100 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; bromine; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; chloroform; water; toluene; acetonitrile;