(E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(6-phenoxy-pyridin-3-yl)-acrylamide

Base Information

Chemical Name:(E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(6-phenoxy-pyridin-3-yl)-acrylamide
CAS No.:118420-45-4
Molecular Formula:C₃₅H₃₈N₄O₂
Molecular Weight:546.712
Hs Code.:

Synonyms:(E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(6-phenoxy-pyridin-3-yl)-acrylamide

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Chemical Property of (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(6-phenoxy-pyridin-3-yl)-acrylamide

Chemical Property:

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Technology Process of (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(6-phenoxy-pyridin-3-yl)-acrylamide

There total 6 articles about (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(6-phenoxy-pyridin-3-yl)-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 118420-45-4
(E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(6-phenoxy-pyridin-3-yl)-acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: NaH / tetrahydrofuran / Ambient temperature

2: hydrogen / 5 percent Pd/C / methanol / 760 Torr / Ambient temperature

3: 1.) NaNO₂, conc. HCl, 2.) Cu₂O / 1.) acetone, methanol, water, 5 deg C, 2.) 35 deg C

4: 4 N KOH / ethanol / Heating

5: 1.) ethyl chlorocarbonate

With copper(I) oxide; hydrogenchloride; potassium hydroxide; hydrogen; chloroformic acid ethyl ester; sodium hydride; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00123a012

Reference yield:

: 28222-02-8
3-nitro-6-phenoxypyridine

: 118420-45-4
(E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(6-phenoxy-pyridin-3-yl)-acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / 5 percent Pd/C / methanol / 760 Torr / Ambient temperature

2: 1.) NaNO₂, conc. HCl, 2.) Cu₂O / 1.) acetone, methanol, water, 5 deg C, 2.) 35 deg C

3: 4 N KOH / ethanol / Heating

4: 1.) ethyl chlorocarbonate

With copper(I) oxide; hydrogenchloride; potassium hydroxide; hydrogen; chloroformic acid ethyl ester; sodium nitrite; palladium on activated charcoal; In methanol; ethanol;
DOI:10.1021/jm00123a012

Reference yield:

: 108-95-2,27073-41-2
phenol

: 118420-45-4
(E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(6-phenoxy-pyridin-3-yl)-acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: NaH / tetrahydrofuran / Ambient temperature

2: hydrogen / 5 percent Pd/C / methanol / 760 Torr / Ambient temperature

3: 1.) NaNO₂, conc. HCl, 2.) Cu₂O / 1.) acetone, methanol, water, 5 deg C, 2.) 35 deg C

4: 4 N KOH / ethanol / Heating

5: 1.) ethyl chlorocarbonate

With copper(I) oxide; hydrogenchloride; potassium hydroxide; hydrogen; chloroformic acid ethyl ester; sodium hydride; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00123a012