Technology Process of 2,4-Diphenyl-6,7-dihydro-5H-cyclopentapyrimidine
There total 10 articles about 2,4-Diphenyl-6,7-dihydro-5H-cyclopentapyrimidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoromethylsulfonic anhydride;
In
dichloromethane;
for 24h;
Ambient temperature;
DOI:10.1021/jo00031a062
- Guidance literature:
-
In
acetonitrile;
at 25 - 60 ℃;
for 27h;
regioselective reaction;
Molecular sieve;
DOI:10.1021/jacs.9b07744
- Guidance literature:
-
Multi-step reaction with 9 steps
1: phosphoric acid / ethanol / 24 h / 120 °C
2: lead dioxide / dichloromethane / 18 h / 25 °C
3: toluene / 100 °C
4: ceric(IV) tetra-n-butylammonium nitrate; trifluorormethanesulfonic acid / dichloromethane / 5 h / 25 °C
5: 4-Methoxybenzenethiol; triethylamine / N,N-dimethyl-formamide / 1 h / 25 °C / Inert atmosphere
6: sodium hydride / N,N-dimethyl-formamide / 3 h / -50 °C / Inert atmosphere
7: ethanethiol; potassium carbonate / N,N-dimethyl-formamide / 6 h / 25 °C / Inert atmosphere
8: manganese(IV) oxide / dichloromethane / 1 h / 25 °C / Inert atmosphere
9: acetonitrile / 27 h / 25 - 60 °C / Molecular sieve
With
manganese(IV) oxide; 4-Methoxybenzenethiol; ceric(IV) tetra-n-butylammonium nitrate; trifluorormethanesulfonic acid; phosphoric acid; sodium hydride; potassium carbonate; lead dioxide; triethylamine; ethanethiol;
In
ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jacs.9b07744
