126918-16-9

Basic information

• Product Name: 1-Propanone, 1-(2,4-difluorophenyl)-2-hydroxy-, (2R)-
• Synonyms: 1-Propanone, 1-(2,4-difluorophenyl)-2-hydroxy-, (2R)-
• CAS NO: 126918-16-9
• Molecular Formula: C₉H₈F₂O₂
• Molecular Weight: 186.1554264
• EINECS: -0
• Mol File: 126918-16-9.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Propanone, 1-(2,4-difluorophenyl)-2-hydroxy-, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-(2,4-difluorophenyl)-2-hydroxy-, (2R)-(126918-16-9)
• EPA Substance Registry System: 1-Propanone, 1-(2,4-difluorophenyl)-2-hydroxy-, (2R)-(126918-16-9)

Safety Data

• Hazardous Substances Data: 126918-16-9(Hazardous Substances Data)

Usage

Uses

(R)-1-(2,4-Difluorophenyl)-2-hydroxy-1-propanone is a useful reagent for producing epoxy alcohol compounds.

Upstream product

• 148505-34-4 Acetic acid 2-(2,4-difluoro-phenyl)-1-methyl-2-oxo-ethyl ester 
• 161457-74-5 (R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-(2,4-difluoro-phenyl)-propan-1-one 
• 161457-73-4 (R)-1-(2,4-Difluoro-phenyl)-2-trimethylsilanyloxy-propan-1-one 
• 126918-15-8 (S)-2-(p-toluenesulfonyloxy)-2',4'-difluoropropiophenone 
• 1550-35-2 2,4-difluorobenzaldehyde 
• 75-07-0 acetaldehyde 
• 127001-03-0 (2R)-2',4'-Difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone 
• 637040-89-2 (2R)-2-(1-ethoxyethoxy)-1-(2,4-difluorophenyl)-1-propanone 
• 247196-88-9 C₁₆H₁₄F₂O₂ 
• 126918-14-7 (2S)-2',4'-Difluoro-2-hydroxypropiophenone 
• 85068-30-0 2',4'-difluoropropiophenone 

Downstream Products

• 126918-20-5 (2R,3R)-2-(2,4-difluorophenyl)butane-1,2,3-triol 
• 124627-86-7 1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole 
• 126918-19-2 (2R,3R)-2-(2,4-Difluorophenyl)-3-(2-tetrahydropyranyloxy)-1,2-butanediol 
• 126917-48-4 (2R,3R)-3-Azido-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol 
• 126918-18-1 (2S,3R)-2-(2,4-difluorophenyl)-1-(dimethylisopropoxysilyl)-3-(2-tetrahydropyranyloxy)-2-butanol 
• 126918-21-6 (2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl dimethanesulfonate 
• 126918-35-2 (1R)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol 
• 150802-86-1 (1R)-1-<(2S)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol 
• 135270-14-3 (R)-1-[(R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl methanesulfonate 
• 132563-81-6 1-(2,4-difluorophenyl)-2-(tetrahydropyranyloxy)propan-1-one 
• 844879-56-7 (3R)-2-(2,4-difluorophenyl)-3-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-1-(1H-1,2,4-triazol-1-yl)2-butanol 
• 212890-35-2 2-[(1R)-1-(3,4,5,6-Tetrahydro-2H-pyran-2-yl)oxyethyl]-2-(2,4-difluorophenyl)oxirane 
• 134779-41-2 (2R,3R)-2-(2,4-difluorophenyl)-3-(methylsulfonyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 135267-12-8 2-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethoxy)tetrahydro-2H-pyran 

Relevant articles and documents

PROCESS FOR PRODUCING EPOXYTRIAZOLE COMPOUND AND INTERMEDIATE THEREFOR

The present invention provides a compound of the formula (I); wherein Ar represents difluorophenyl group, which is useful as an intermediate in a process for producing an epoxytriazole compound of the formula (VII); wherein Ar represents difluorophenyl group, which is a synthetic intermediate of antifungal agents. The present invention also provides a process for producing a compound of the formula (VII) which comprises epoxydation step, deprotection step, reaction step with a compound represented by RSO2X, and reaction step with 1,2,4-triazole; or comprises epoxydation step, reaction step with 1,2,4-triazole, deprotection step, reaction step with a compound represented by RSO2X and treatment step by a base.

Enantioselective Synthesis of α-Hydroxy Ketones via Benzaldehyde Lyase-Catalyzed C-C Bond Formation Reaction

(R)-Benzoins and (R)-2-hydroxypropiophenone derivatives are formed on a preparative scale by benzaldehyde lyase (BAL)-catalyzed C-C bond formation from aromatic aldehydes and acetaldehyde in aqueous buffer/ DMSO solution with remarkable ease in high chemical yield and high optical purity. The substrate range of this thiamin diphosphate-dependent enzyme was examined with respect to a broad applicability of this benzoin condensation-type reaction in stereoselective synthesis.

Simple chemoenzymatic access to enantiopure pharmacologically interesting (R)-2-hydroxypropiophenones

A chemoenzymatic synthesis of pharmacological interesting (R)-2-hydroxypropiophenones starting from propiophenone derivatives is described. Manganese(III) acetate-mediated acetoxylation followed by fungus-mediated hydrolysis of propiophenone derivatives affords (R)-2-hydroxypropiophenones in high enantiomeric excess.