methyl 2-chloro-2-(1-{2-[(phenylsulfonyl)amino]phenylthio}cyclopropyl)acetate

Base Information

• Chemical Name: methyl 2-chloro-2-(1-{2-[(phenylsulfonyl)amino]phenylthio}cyclopropyl)acetate
• CAS No.: 552832-43-6
• Molecular Formula: C₁₈H₁₈ClNO₄S₂
• Molecular Weight: 411.93

Synonyms:methyl 2-chloro-2-(1-{2-[(phenylsulfonyl)amino]phenylthio}cyclopropyl)acetate

Chemical Property of methyl 2-chloro-2-(1-{2-[(phenylsulfonyl)amino]phenylthio}cyclopropyl)acetate

Chemical Property:

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Technology Process of methyl 2-chloro-2-(1-{2-[(phenylsulfonyl)amino]phenylthio}cyclopropyl)acetate

There total 2 articles about methyl 2-chloro-2-(1-{2-[(phenylsulfonyl)amino]phenylthio}cyclopropyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-chloro-2-cyclopropylideneacetate (82979-45-1) → methyl 2-chloro-2-(1-{2-[(phenylsulfonyl)amino]phenylthio}cyclopropyl)acetate (552832-43-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / Et₃N / CH₂Cl₂ / 24 h / 20 °C

2: 80 percent / pyridine / CH₂Cl₂ / 24 h / 20 °C

With pyridine; triethylamine; In dichloromethane;

DOI:10.1002/ejoc.200390154

Reference yield:

2-amino-benzenethiol (137-07-5) → methyl 2-chloro-2-(1-{2-[(phenylsulfonyl)amino]phenylthio}cyclopropyl)acetate (552832-43-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / Et₃N / CH₂Cl₂ / 24 h / 20 °C

2: 80 percent / pyridine / CH₂Cl₂ / 24 h / 20 °C

With pyridine; triethylamine; In dichloromethane;

DOI:10.1002/ejoc.200390154

Reference yield: 77.0%

methyl 2-chloro-2-(1-{2-[(phenylsulfonyl)amino]phenylthio}cyclopropyl)acetate (552832-43-6) → methyl 4-(phenylsulfonyl)-3,4-dihydrospiro([2H][1,4]benzothiazine-2,1'-cyclopropane)-3-carboxylate (552832-45-8)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 70 ℃; for 2h;

DOI:10.1002/ejoc.200390154

upstream raw materials:

methyl 2-chloro-2-cyclopropylideneacetate

2-amino-benzenethiol

Downstream raw materials:

methyl 4-(phenylsulfonyl)-3,4-dihydrospiro([2H][1,4]benzothiazine-2,1'-cyclopropane)-3-carboxylate

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