N-((1R,2S)-1-hydroxy-3-phenyl-1-((R)-pyrrolidin-2-yl)propan-2-yl)-5-((R)-2-(4-methylthiazol-2-yl)pyrrolidine-1-carbonyl)chroman-7-carboxamide

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Chemical Name:N-((1R,2S)-1-hydroxy-3-phenyl-1-((R)-pyrrolidin-2-yl)propan-2-yl)-5-((R)-2-(4-methylthiazol-2-yl)pyrrolidine-1-carbonyl)chroman-7-carboxamide
CAS No.:1342299-30-2
Molecular Formula:C₃₂H₃₈N₄O₄S
Molecular Weight:574.744
Hs Code.:

Synonyms:N-((1R,2S)-1-hydroxy-3-phenyl-1-((R)-pyrrolidin-2-yl)propan-2-yl)-5-((R)-2-(4-methylthiazol-2-yl)pyrrolidine-1-carbonyl)chroman-7-carboxamide

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Chemical Property of N-((1R,2S)-1-hydroxy-3-phenyl-1-((R)-pyrrolidin-2-yl)propan-2-yl)-5-((R)-2-(4-methylthiazol-2-yl)pyrrolidine-1-carbonyl)chroman-7-carboxamide

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Technology Process of N-((1R,2S)-1-hydroxy-3-phenyl-1-((R)-pyrrolidin-2-yl)propan-2-yl)-5-((R)-2-(4-methylthiazol-2-yl)pyrrolidine-1-carbonyl)chroman-7-carboxamide

There total 14 articles about N-((1R,2S)-1-hydroxy-3-phenyl-1-((R)-pyrrolidin-2-yl)propan-2-yl)-5-((R)-2-(4-methylthiazol-2-yl)pyrrolidine-1-carbonyl)chroman-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1342299-98-2
C₃₇H₄₆N₄O₆S

: 1342299-30-2
N-((1R,2S)-1-hydroxy-3-phenyl-1-((R)-pyrrolidin-2-yl)propan-2-yl)-5-((R)-2-(4-methylthiazol-2-yl)pyrrolidine-1-carbonyl)chroman-7-carboxamide

Guidance literature:: C₃₇H₄₆N₄O₆S; With hydrogenchloride; In 1,4-dioxane; methanol; for 1h; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; water; for 0.0833333h;

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1342299-30-2
N-((1R,2S)-1-hydroxy-3-phenyl-1-((R)-pyrrolidin-2-yl)propan-2-yl)-5-((R)-2-(4-methylthiazol-2-yl)pyrrolidine-1-carbonyl)chroman-7-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

2.1: N,N-diethylaniline / 15 h / 200 °C

3.1: copper diacetate / acetonitrile / 46 h / 20 °C

4.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / Inert atmosphere

5.1: hydrogen / palladium 10% on activated carbon / methanol

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0 - 20 °C

6.2: pH 2

6.3: 0 - 20 °C / Inert atmosphere

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 40 °C

7.2: pH 2

8.1: benzotriazol-1-ol / dichloromethane / 0.5 h / 0 °C

8.2: 1 h / 0 °C

8.3: 0 - 20 °C

9.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h / Inert atmosphere

9.2: 0.08 h

With hydrogenchloride; water; hydrogen; copper diacetate; potassium carbonate; benzotriazol-1-ol; N,N-diethylaniline; sodium hydroxide; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 869527-43-5
tert-butyl (R)-2-((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenyl-propyl)-pyrrolidine-1-carboxylate

: 1342299-30-2
N-((1R,2S)-1-hydroxy-3-phenyl-1-((R)-pyrrolidin-2-yl)propan-2-yl)-5-((R)-2-(4-methylthiazol-2-yl)pyrrolidine-1-carbonyl)chroman-7-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium(II) hydroxide / methanol / 17 h

2.1: benzotriazol-1-ol / dichloromethane / 0.5 h / 0 °C

2.2: 1 h / 0 °C

2.3: 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h / Inert atmosphere

3.2: 0.08 h

With hydrogenchloride; hydrogen; benzotriazol-1-ol; palladium(II) hydroxide; In 1,4-dioxane; methanol; dichloromethane;