tert-butyl (R)-2-((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenyl-propyl)-pyrrolidine-1-carboxylate

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Chemical Name:tert-butyl (R)-2-((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenyl-propyl)-pyrrolidine-1-carboxylate
CAS No.:869527-43-5
Molecular Formula:C₃₂H₄₀N₂O₃
Molecular Weight:500.681
Hs Code.:

Synonyms:tert-butyl (R)-2-((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenyl-propyl)-pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (R)-2-((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenyl-propyl)-pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (R)-2-((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenyl-propyl)-pyrrolidine-1-carboxylate

There total 6 articles about tert-butyl (R)-2-((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenyl-propyl)-pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 123054-12-6,123808-74-2,136370-73-5,111060-64-1
(2S)-N,N-dibenzylphenylalaninal

: 869527-43-5
tert-butyl (R)-2-((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenyl-propyl)-pyrrolidine-1-carboxylate

Guidance literature:: tert-butyl pyrrolidine-1-carboxylate; With (2-methylpropyl)lithium; sparteine; In diethyl ether; at -78 ℃; for 2.21667h;

(2S)-N,N-dibenzylphenylalaninal; In diethyl ether; for 0.416667h;

With acetic acid; In diethyl ether;

Reference yield: 52.0%

: C₃₂H₃₆N₂O₃

: tert-butyl (S)-2-((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenylpropyl)-pyrrolidine-1-carboxylate

: 869527-43-5
tert-butyl (R)-2-((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenyl-propyl)-pyrrolidine-1-carboxylate

Guidance literature:: With 10 wt% platinum on carbon; hydrogen; In methanol; under 760.051 Torr;
DOI:10.1021/acs.jmedchem.7b01304

Reference yield: 43.0%

: 123054-12-6,123808-74-2,136370-73-5,111060-64-1
(2S)-N,N-dibenzylphenylalaninal

: 86953-79-9
tert-butyl pyrrolidine-1-carboxylate

: 869527-43-5
tert-butyl (R)-2-((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenyl-propyl)-pyrrolidine-1-carboxylate

Guidance literature:: tert-butyl pyrrolidine-1-carboxylate; With sec.-butyllithium; (-)-sparteine; In diethyl ether; at -78 ℃; for 2h;

(2S)-N,N-dibenzylphenylalaninal; In diethyl ether; for 0.333333h; Cooling;

With acetic acid; In diethyl ether; at 20 ℃; Cooling;