2,2-difluoro-2-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-phenylethanone

Base Information

• Chemical Name: 2,2-difluoro-2-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-phenylethanone
• CAS No.: 1150587-84-0
• Molecular Formula: C₂₄H₂₁F₂NO₂
• Molecular Weight: 393.433
• Mol file: 1150587-84-0.mol

Synonyms:2,2-difluoro-2-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-phenylethanone

Chemical Property of 2,2-difluoro-2-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-phenylethanone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2,2-difluoro-2-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-phenylethanone

There total 2 articles about 2,2-difluoro-2-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline (78317-83-6) + 2,2-difluoro-1-phenyl-1-trimethylsiloxyethene (86340-78-5) → 2,2-difluoro-2-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-phenylethanone (1150587-84-0)

Guidance literature:

With tert.-butylhydroperoxide; copper(I) bromide; In decane; dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ol900541n

Reference yield: 77.0%

2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline (78317-83-6) + 2,2,4,4,4-pentafluoro-3,3-dihydroxy-1-phenylbutan-1-one (1259998-89-4) → 2,2-difluoro-2-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-phenylethanone (1150587-84-0)

Guidance literature:

2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline; With tetrachloromethane; tris(2,2'-bipyridyl)ruthenium dichloride; In acetonitrile; at 20 ℃; for 24h; Irradiation; Inert atmosphere;

2,2,4,4,4-pentafluoro-3,3-dihydroxy-1-phenylbutan-1-one; With triethylamine; In acetonitrile; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1039/c4cc02768j

upstream raw materials:

2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

2,2-difluoro-1-phenyl-1-trimethylsiloxyethene

2,2,4,4,4-pentafluoro-3,3-dihydroxy-1-phenylbutan-1-one