1259998-89-4Relevant articles and documents
Detrifluoroacetylative Generation of Halogenated Enolates: Practical Access to Perhalogenated Ketones and Alkenes
Balaraman, Kaluvu,Moskowitz, Max,Liu, Yang,Wolf, Christian
, p. 2376 - 2384 (2016)
Sequential chlorination/fluorination of aromatic trifluoroacetylated ketones gives 1-aryl 2-chloro-2,4,4,4-tetrafluorobutan-1,3-dione hydrates that are used for the synthesis of ketones and alkenes exhibiting a terminal bromochlorofluoromethyl group. The
A accompanies two fluorine substituted tetrahydronaphthalene ketone compound and its preparation method
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, (2019/07/04)
The invention provides a accompanies two fluorine substituted tetrahydronaphthalene ketone compound and its preparation method. The accompanies two fluorine substituted tetrahydronaphthalene ketone compound, characterized in that its structure such as for
Beta-iododifluoroacetone derivative and preparation method thereof
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, (2020/01/12)
The invention relates to a beta-iododifluoroacetone derivative and a preparation method thereof. The preparation method comprises the following steps: dissolving an iododifluoroketone compound raw material and an olefin raw material in a solvent, then add
Palladium-Catalyzed Benzodifluoroalkylation of Alkynes: A Route to Fluorine-Containing 1,1-Diarylethylenes
Liang, Junqing,Huang, Guozhi,Peng, Peng,Zhang, Tianyu,Wu, Jingjing,Wu, Fanhong
, p. 2221 - 2227 (2018/04/17)
A palladium(0)-catalyzed three-component reaction of 2-iodo-2,2-difluoroacetophenones, alkynes and arylboronic acids is introduced for the synthesis of 1-benzoyldifluoromethyl-2,2-diphenylethylenes in good yields and with excellent stereoselectivity. The
Synthesis of α,α-difluorobenzoyl oxygen heterocycles via the radical reaction of 2-iodo-2,2-difluoroacetophenones with unsaturated acids or unsaturated alcohols
Chen, Heng,Wang, Jiexiong,Wu, Jingjing,Kuang, Yujia,Wu, Fanhong
, p. 41 - 46 (2017/06/14)
A convenient and facile method for the direct synthesis of α,α-difluorobenzoyl lactones or cyclic ethers via the radical cyclization reaction of 2-iodo-2,2-difluoroacetophenone with unsaturated acids or alcohols was reported.
One-pot synthesis of difluoromethyl ketones by a difluorination/fragmentation process
Leng, Daniel J.,Black, Conor M.,Pattison, Graham
supporting information, p. 1531 - 1535 (2016/02/10)
Difluoromethyl ketones are an under-studied class of ketones which have great potential as useful building blocks for materials and drug design. Here we report a simple and convenient synthesis of this class of compounds via a one-pot difluorination/fragm
Synthesis of difluoroalkyl-γ-butyrolactones from iododifluoromethyl ketones and 4-pentenoic acids
Wang, Jie-Xiong,Wu, Jing-Jing,Chen, Heng,Zhang, Shao-Wu,Wu, Fan-Hong
, p. 1381 - 1384 (2015/10/28)
A convenient and efficient approach for difluoroalkyl-containing γ-butyrolactones via the radical addition reaction of iododifluoromethyl ketones with 4-pentenoic acids initiated by AIBN in CH3CN at 60 °C was reported. Various difluoroalkyl-containing δ-valerolactones were also synthesized under this reaction conditions.
Synthesis of pentafluorinated β-hydroxy ketones
Zhang, Peng,Wolf, Christian
, p. 8840 - 8844 (2012/11/07)
The LHMDS-promoted in situ generation of difluoroenolates from readily available 1-aryl and 1-alkyl 2,2,4,4,4-pentafluorobutan-1,3-dione hydrates has been used to produce a series of pentafluorinated β-hydroxy ketones in up to 95% yield. The reaction proc
Towards greener fluorine organic chemistry: Direct electrophilic fluorination of carbonyl compounds in water and under solvent-free reaction conditions
Stavber, Gaj,Stavber, Stojan
experimental part, p. 2838 - 2846 (2011/02/21)
Selective and efficient fluorination of organic 1,3-dicarbonyl compounds was achieved using the electrophilic fluorinating reagents Selectfluor TM F-TEDA-BF4 (1-chloromethyl-4-fluoro-1,4- diazoniabicyclo[2.2.2]octane bis-tetrafluoroborate) in aqueous medium or AccufluorTM NFSi (N-fluorobenzenesulfonimide) under solvent-free reaction conditions (SFRC). Under both reaction conditions cyclic 1,3-dicarbonyl compounds were transformed into 2-fluoro-substituted derivatives and acyclic analogues into 2,2-difluoro-substituted compounds, while the reactions of 1-trifluoromethyl-substituted 1,3-dicarbonyls in water resulted in the formation of 2,2-difluoro-3,3-dihydroxy-1-one derivatives. The reactivity of the starting material in water was found to be dependent on its enolizability, hydrophobic interactions and aggregate state at the reaction temperature. Reactions under SFRC proceeded in the molten eutectic phase of the reactants. The technique of competitive reactivity was used in order to evaluate and better understand the effects of reaction conditions on the course of these reactions.