(R)-methyl 2-(4-(benzyloxy)benzyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Base Information

Chemical Name:(R)-methyl 2-(4-(benzyloxy)benzyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
CAS No.:1346787-52-7
Molecular Formula:C₂₇H₂₆N₂O₃
Molecular Weight:426.515
Hs Code.:

Synonyms:(R)-methyl 2-(4-(benzyloxy)benzyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

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Chemical Property of (R)-methyl 2-(4-(benzyloxy)benzyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

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Technology Process of (R)-methyl 2-(4-(benzyloxy)benzyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

There total 2 articles about (R)-methyl 2-(4-(benzyloxy)benzyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 5544-60-5
4-(benzyloxy)benzyl bromide

: 81075-61-8
(R)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester

: 1346787-52-7
(R)-methyl 2-(4-(benzyloxy)benzyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 5h; Reflux;
DOI:10.1016/j.bmc.2011.09.020

Reference yield:

: 72002-54-1
(3R)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid

: 1346787-52-7
(R)-methyl 2-(4-(benzyloxy)benzyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 3 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / Reflux

With thionyl chloride; N-ethyl-N,N-diisopropylamine; In acetonitrile;
DOI:10.1016/j.bmc.2011.09.020

Reference yield: 43.0%

: 1346787-52-7
(R)-methyl 2-(4-(benzyloxy)benzyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

: 1346787-56-1
(R)-methyl 2-(4-hydroxybenzyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 5h; under 1125.11 Torr;
DOI:10.1016/j.bmc.2011.09.020