1,3-Dioxolane, 2,2-dimethyl-4-[(tetradecyloxy)methyl]-

Base Information

• Chemical Name: 1,3-Dioxolane, 2,2-dimethyl-4-[(tetradecyloxy)methyl]-
• CAS No.: 13879-87-3
• Molecular Formula: C₂₀H₄₀O₃
• Molecular Weight: 328.536
• Mol file: 13879-87-3.mol

Synonyms:1,3-Dioxolane, 2,2-dimethyl-4-[(tetradecyloxy)methyl]-

Chemical Property of 1,3-Dioxolane, 2,2-dimethyl-4-[(tetradecyloxy)methyl]-

Chemical Property:

• PSA: 27.69000
• LogP: 5.85560

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Dioxolane, 2,2-dimethyl-4-[(tetradecyloxy)methyl]-

There total 5 articles about 1,3-Dioxolane, 2,2-dimethyl-4-[(tetradecyloxy)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-Bromotetradecane (112-71-0) + (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol (100-79-8,36543-79-0) → 4-(n-tetradecyloxymethyl)-2,2-dimethyl-1,3-dioxolane (13879-87-3)

Guidance literature:

(R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol; With sodium hydride; In toluene; for 0.333333h; Inert atmosphere;

1-Bromotetradecane; In toluene; Inert atmosphere; Reflux;

DOI:10.1002/cbdv.201000274

Reference yield: 68.0%

1-Tetradecanol (112-72-1) + solketal tosylate (23737-51-1,7305-59-1) → 4-(n-tetradecyloxymethyl)-2,2-dimethyl-1,3-dioxolane (13879-87-3)

Guidance literature:

1-Tetradecanol; With sodium hydride; In 1,2-dimethoxyethane; mineral oil; for 1h; Reflux;

solketal tosylate; In 1,2-dimethoxyethane; ethylene glycol; mineral oil; at 100 ℃; for 48h;

DOI:10.3390/md16040101

Reference yield:

myristyl chloride (2425-54-9) + (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol (100-79-8,36543-79-0) → 4-(n-tetradecyloxymethyl)-2,2-dimethyl-1,3-dioxolane (13879-87-3)

Guidance literature:

With sodium hydride; sodium iodide; In N,N-dimethyl-formamide; at 50 ℃; for 16h;

upstream raw materials:

1-Bromotetradecane

(R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol

myristyl chloride

1-Tetradecanol

Downstream raw materials:

1-myristyl glycerol

dibenzyl 3-O-tetradecyl-rac-glycero-1-phosphate

Refernces

• 1、 Pinault, Michelle,Guimaraes, Cyrille,Couthon, Hélène,Thibonnet, Jér?me,Fontaine, Delphine,Chant?me, Aurélie,Chevalier, Stephan,Besson, Pierre,Jaffrès, Paul-Alain,Vandier, Christophe. "Synthesis of alkyl-glycerolipids standards for gas chromatography analysis: Application for chimera and shark liver oils". . . Retrieved 2018/04/16.
• 2、 Huang, Zhaohua,Szoka Jr., Francis C.. "Sterol-modified phospholipids: Cholesterol and phospholipid chimeras with improved biomembrane properties". supporting information; experimental part. p. 15702 - 15712. Retrieved 2009/03/12.