Technology Process of C16H14BrF2N5O2S
There total 7 articles about C16H14BrF2N5O2S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-bromo-5-trimethylsilylethynylpyridine;
With
potassium fluoride;
In
methanol;
at 45 ℃;
C9H10F2N4O2S;
With
sodium L-ascorbate;
copper(II) sulfate;
In
methanol; water;
at 45 ℃;
for 72h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium nitrate; sulfuric acid / 2 h / -10 - 20 °C
2.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 10343.2 Torr / autoclave
3.1: pyridine / dichloromethane / 16 h / 20 °C
4.1: hydrogenchloride / ethanol; water / 2 h / 80 °C
5.1: trifluoroacetic acid; sodium nitrite / 0.5 h / 0 °C
5.2: 0.25 h
6.1: potassium fluoride / methanol / 20 °C
6.2: 72 h / 45 °C
With
pyridine; hydrogenchloride; potassium fluoride; sulfuric acid; hydrogen; potassium nitrate; trifluoroacetic acid; sodium nitrite;
palladium 10% on activated carbon;
In
methanol; ethanol; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 10343.2 Torr / autoclave
2.1: pyridine / dichloromethane / 16 h / 20 °C
3.1: hydrogenchloride / ethanol; water / 2 h / 80 °C
4.1: trifluoroacetic acid; sodium nitrite / 0.5 h / 0 °C
4.2: 0.25 h
5.1: potassium fluoride / methanol / 20 °C
5.2: 72 h / 45 °C
With
pyridine; hydrogenchloride; potassium fluoride; hydrogen; trifluoroacetic acid; sodium nitrite;
palladium 10% on activated carbon;
In
methanol; ethanol; dichloromethane; water;
