2-fluoro-3-methyl-4-[2-(1-methyl-1H-pyrazol-4-yl)-pyridin-4-yloxy]-phenylamine

Base Information

Chemical Name:2-fluoro-3-methyl-4-[2-(1-methyl-1H-pyrazol-4-yl)-pyridin-4-yloxy]-phenylamine
CAS No.:1020173-29-8
Molecular Formula:C₁₆H₁₅FN₄O
Molecular Weight:298.32
Hs Code.:

Synonyms:2-fluoro-3-methyl-4-[2-(1-methyl-1H-pyrazol-4-yl)-pyridin-4-yloxy]-phenylamine

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Chemical Property of 2-fluoro-3-methyl-4-[2-(1-methyl-1H-pyrazol-4-yl)-pyridin-4-yloxy]-phenylamine

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Technology Process of 2-fluoro-3-methyl-4-[2-(1-methyl-1H-pyrazol-4-yl)-pyridin-4-yloxy]-phenylamine

There total 5 articles about 2-fluoro-3-methyl-4-[2-(1-methyl-1H-pyrazol-4-yl)-pyridin-4-yloxy]-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1020173-28-7
4-(2-chloro-pyridin-4-yloxy)-2-fluoro-3-methyl-phenylamine

: 761446-44-0
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1020173-29-8
2-fluoro-3-methyl-4-[2-(1-methyl-1H-pyrazol-4-yl)-pyridin-4-yloxy]-phenylamine

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 0.25h; Heating / reflux;

Reference yield:

: 1020173-27-6
4-amino-3-fluoro-2-methyl-phenol

: 1020173-29-8
2-fluoro-3-methyl-4-[2-(1-methyl-1H-pyrazol-4-yl)-pyridin-4-yloxy]-phenylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.5 h / 20 °C

1.2: 100 °C

2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate; sodium carbonate; In 1,2-dimethoxyethane; N,N-dimethyl acetamide; water;

Reference yield:

: 443-84-5
2,6-difluorotoluene

: 1020173-29-8
2-fluoro-3-methyl-4-[2-(1-methyl-1H-pyrazol-4-yl)-pyridin-4-yloxy]-phenylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; nitric acid / 0.5 h / -10 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 100 °C

3.1: hydrogen; palladium 10% on activated carbon / methanol / 760.05 Torr

4.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.5 h / 20 °C

4.2: 100 °C

5.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; nitric acid; sodium carbonate; potassium carbonate; In methanol; 1,2-dimethoxyethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;