443-84-5

Basic information

• Product Name: 2,6-Difluorotoluene
• Synonyms: 2,6-DIFLUOROTOLUENE;2.6-Difluoro methyl benzene;2,6-Difluorotoluene,98%;2,6-Difluorotoluene,99%;2,6-Difluorotoluene 99%;Benzene, 1,3-difluoro-2-methyl-
• CAS NO: 443-84-5
• Molecular Formula: C₇H₆F₂
• Molecular Weight: 128.12
• EINECS: -0
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Halogen toluene;Miscellaneous;Aryl;C7;Halogenated Hydrocarbons;Aryl Fluorinated Building Blocks;Building Blocks;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Hydrocarbons;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks
• Mol File: 443-84-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 112 °C740 mm Hg(lit.)
• Flash Point: 50 °F
• Appearance: colorless to light yellow liquid
• Density: 1.129 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.292mmHg at 25°C
• Refractive Index: n20/D 1.453(lit.)
• Storage Temp.: Flammables area
• BRN: 1932656
• CAS DataBase Reference: 2,6-Difluorotoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Difluorotoluene(443-84-5)
• EPA Substance Registry System: 2,6-Difluorotoluene(443-84-5)

Safety Data

• Hazard Codes: F,F+
• Statements: 11
• Safety Statements: 16-29-33
• RIDADR: UN 1993 3/PG 2
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 443-84-5(Hazardous Substances Data)

Usage

Chemical Properties

colorless to light yellow liqui

Uses

2,6-Difluorotoluene was used to generate jet-cooled 2,6-difluorobenzyl radical and to investigate its vibronically resolved emission spectra.

General Description

2,6-Difluorotoluene reacts with chlorine to give 2,6-difluorobenzyl chloride, which gets converted to 2,6-difluorobenzaldehyde through Sommelet′s reaction. Six-fold potential for internal methyl rotation in first singlet excited state and cation ground state of 2,6-difluorotoluene has been determined.

InChI:InChI=1/C7H8FN/c1-5-6(8)3-2-4-7(5)9/h2-4H,9H2,1H3

Upstream product

• 443-86-7 3-fluoro-2-methylaniline 
• 149838-77-7 Sodium; 2,4-difluoro-3-methyl-benzenesulfonate 
• 372-18-9 1,3-Difluorobenzene 
• 74-88-4 methyl iodide 
• 141407-30-9 2,4-Difluoro-3-methylbenzene sulfonyl fluoride 
• 118-69-4 2,6-dichlorotoluene 
• 69145-58-0 2,4-Dichloro-3-methylbenzenesulfonyl chloride 
• 769-10-8 1-fluoro-2-methyl-3-nitrobenzene 
• 603-83-8 3-nitro-o-tolylamine 

Downstream Products

• 437-81-0 2,6-difluorobenzaldehyde 
• 384-99-6 2-dibromomethyl-1,3-difluoro-benzene 
• 697-73-4 2,6-difluorobenzyl chloride 
• 85118-00-9 2,6-Difluorobenzyl bromide 
• 79562-49-5 2,4-difluoro-3-methyl-nitrobenzene 
• 76350-70-4 2,4-difluoro-3-methyl-aniline 
• 79562-50-8 2-[(2,4-Difluoro-3-methyl-phenylamino)-methylene]-malonic acid diethyl ester 
• 130849-01-3 1-amino-2-(2,6-difluorophenyl)ethylphosphonic acid 
• 130848-82-7 [1-Amino-2-(2,6-difluoro-phenyl)-ethyl]-phosphonic acid diethyl ester 
• 131622-46-3 (2-(2,6-Difluoro-phenyl)-1-{[1-phenyl-meth-(E)-ylidene]-amino}-ethyl)-phosphonic acid diethyl ester 
• 2647-31-6 2,6-Difluor-α-cyan-stilben 
• 654-01-3 (2,6-difluorophenyl)acetonitrile 
• 1525-46-8 2,6-Difluor-4'-dimethylamino-α-cyan-stilben 
• 4619-90-3 <2,6-Difluor-phenyl>-<4'-dimethylamino-phenyl>-α-cyan-azomethin 

Relevant articles and documents

Sulfonyl chloride as a disposable electron withdrawing substituent in halex fluorinations

Syntheses of 1,3-difluorobenzene and 2,6-difluorotoluene are described via chlorosulfonation, catalytic Halex-fluorination, and desulfination of 1,3-dichlorobenzene and 2,6-dichlorotoluene.

REACTIONS OF AROMATIC COMPOUNDS WITH NUCLEOPHILIC REAGENTS IN LIQUID AMMONIA. REACTION OF POLYFLUORINATED DERIVATIVES OF BENZENE WITH SODIUM AMIDE

Under the influence of sodium amide in liquid ammonia at a temperature no higher than -33 deg C pentafluorobenzene, 1,2,4,5-tetrafluorobenzene, and 1,3-difluorobenzene undergo deprotonation with the formation of fluorinated phenyl anions, which are resistant to the elimination of a fluoride ion and can be detected by the formation of the products from interaction with electrophiles (with the initial compound in the first case and with methyl iodide in the other two cases). 1,3,5-Trifluorobenzene behaves similarly in reaction with one equivalent of sodium amide, but with two equivalents of sodium amide this compound and 1,2,3,5-tetrafluorob enzene undergo substitution of a fluorine atom by an amino group with the formation of 3,5-di- and 3,4,5-trifluoroanilines respectively.This is clearly due to the double deprotonation of these compounds with the formation of polyfluorinated m-phenylene dianions, which are then converted with the elimination of a fluoride ion into the corresponding dehydrophenyl anions.

The synthesis of ortho-substituted 2-diethylaminoethyl benzoates as potential local anaesthetics.

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