1,3-difluoro-2-methyl-4-nitrobenzene

Base Information

• Chemical Name: 1,3-difluoro-2-methyl-4-nitrobenzene
• CAS No.: 79562-49-5
• Molecular Formula: C7H5F2NO2
• Molecular Weight: 173.119
• Hs Code.: 2904909090
• Mol file: 79562-49-5.mol

Synonyms:1,3-difluoro-2-methyl-4-nitro-benzene

Chemical Property of 1,3-difluoro-2-methyl-4-nitrobenzene

Chemical Property:

• Vapor Pressure: 0.07mmHg at 25°C
• Refractive Index: 1.508
• Boiling Point: 237.2 °C at 760 mmHg
• Flash Point: 108.8 °C
• PSA: 45.82000
• Density: 1.374 g/cm³
• LogP: 2.70460
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99%, ^*data from raw suppliers

1,3-difluoro-2-methyl-4-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,6-Difluoro-3-nitrotoluene used as a intermediate in organic synthesis, pharmaceutical and chemical research.

Technology Process of 1,3-difluoro-2-methyl-4-nitrobenzene

There total 1 articles about 1,3-difluoro-2-methyl-4-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2,6-difluorotoluene (443-84-5) → 2,4-difluoro-3-methyl-nitrobenzene (79562-49-5)

Guidance literature:

With sulfuric acid; nitric acid; at 20 - 25 ℃; for 1.5h;

DOI:10.1248/cpb.30.3530

Reference yield: 94.0%

2,4-difluoro-3-methyl-nitrobenzene (79562-49-5) + aniline (62-53-3) → (3-fluoro-2-methyl-6-nitrophenyl)phenylamine (1393177-51-9)

Guidance literature:

aniline; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

2,4-difluoro-3-methyl-nitrobenzene; In tetrahydrofuran; at -78 ℃; for 0.5h;

With water; In tetrahydrofuran;

Reference yield: 85.0%

tin(II)chloride dihydrate + 2,4-difluoro-3-methyl-nitrobenzene (79562-49-5) → 2,4-difluoro-3-methyl-aniline (76350-70-4)

Guidance literature:

In hydrogenchloride; water;

upstream raw materials:

2,6-difluorotoluene

Downstream raw materials:

2,4-difluoro-3-methyl-aniline

2-[(2,4-Difluoro-3-methyl-phenylamino)-methylene]-malonic acid diethyl ester

1-benzyloxy-3-fluoro-2-methyl-4-nitro-benzene

C₁₄H₈ClFN₂O₃

Refernces

• 1、 -. "METHODS AND COMPOSITIONS FOR THE TREATMENT OF MYELOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES". Paragraph 00273. . Retrieved 2013/03/26.
• 2、 -. "IMIDAZOLINYLMETHYL ARYL SULFONAMIDE". Page/Page column 5. . Retrieved 2009/08/16.