4(e)-(2,5-bis-benzyloxy-3,4-dicyano-phenyl)-cyclohexane-(a)-carbaldehyde

Base Information

• Chemical Name: 4(e)-(2,5-bis-benzyloxy-3,4-dicyano-phenyl)-cyclohexane-(a)-carbaldehyde
• CAS No.: 179617-87-9
• Molecular Formula: C₂₉H₂₆N₂O₃
• Molecular Weight: 450.537
• Mol file: 179617-87-9.mol

Synonyms:4(e)-(2,5-bis-benzyloxy-3,4-dicyano-phenyl)-cyclohexane-(a)-carbaldehyde

Chemical Property of 4(e)-(2,5-bis-benzyloxy-3,4-dicyano-phenyl)-cyclohexane-(a)-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4(e)-(2,5-bis-benzyloxy-3,4-dicyano-phenyl)-cyclohexane-(a)-carbaldehyde

There total 4 articles about 4(e)-(2,5-bis-benzyloxy-3,4-dicyano-phenyl)-cyclohexane-(a)-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-(2,5-Bis-benzyloxy-3,4-dicyano-phenyl)-cyclohexanecarboxylic acid methyl ester (179617-85-7) → 4(e)-(2,5-bis-benzyloxy-3,4-dicyano-phenyl)-cyclohexane-(a)-carbaldehyde (179617-87-9)

Guidance literature:

With diisobutylaluminium hydride; In diethyl ether; dichloromethane; at -95 ℃; for 1h;

DOI:10.1016/0040-4020(96)00405-X

Reference yield:

benzyl bromide (100-39-0) → 4(e)-(2,5-bis-benzyloxy-3,4-dicyano-phenyl)-cyclohexane-(a)-carbaldehyde (179617-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / K₂CO₃ / acetone / 1 h / Heating

2: 94 percent / diisobutylaluminium hydride / diethyl ether; CH₂Cl₂ / 1 h / -95 °C

With diisobutylaluminium hydride; potassium carbonate; In diethyl ether; dichloromethane; acetone;

DOI:10.1016/0040-4020(96)00405-X

Reference yield:

2-<4-(Methoxycarbonyl)cyclohexyl>-p-benzochinon → 4(e)-(2,5-bis-benzyloxy-3,4-dicyano-phenyl)-cyclohexane-(a)-carbaldehyde (179617-87-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 98percent H₂SO₄ / propan-2-ol; H₂O / 10 h / 20 - 30 °C

2: 97 percent / K₂CO₃ / acetone / 1 h / Heating

3: 94 percent / diisobutylaluminium hydride / diethyl ether; CH₂Cl₂ / 1 h / -95 °C

With sulfuric acid; diisobutylaluminium hydride; potassium carbonate; In diethyl ether; dichloromethane; water; isopropyl alcohol; acetone;

DOI:10.1016/0040-4020(96)00405-X

upstream raw materials:

4-(2,5-Bis-benzyloxy-3,4-dicyano-phenyl)-cyclohexanecarboxylic acid methyl ester

benzyl bromide

4-(3,4-Dicyano-2,5-dihydroxy-phenyl)-cyclohexanecarboxylic acid methyl ester