4-(3,4-Dicyano-2,5-dihydroxy-phenyl)-cyclohexanecarboxylic acid methyl ester

Base Information

• Chemical Name: 4-(3,4-Dicyano-2,5-dihydroxy-phenyl)-cyclohexanecarboxylic acid methyl ester
• CAS No.: 179617-83-5
• Molecular Formula: C₁₆H₁₆N₂O₄
• Molecular Weight: 300.314
• Mol file: 179617-83-5.mol

Synonyms:4-(3,4-Dicyano-2,5-dihydroxy-phenyl)-cyclohexanecarboxylic acid methyl ester

Chemical Property of 4-(3,4-Dicyano-2,5-dihydroxy-phenyl)-cyclohexanecarboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3,4-Dicyano-2,5-dihydroxy-phenyl)-cyclohexanecarboxylic acid methyl ester

There total 1 articles about 4-(3,4-Dicyano-2,5-dihydroxy-phenyl)-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium cyanide (151-50-8) + 2-<4-(Methoxycarbonyl)cyclohexyl>-p-benzochinon → 4-(3,4-Dicyano-2,5-dihydroxy-phenyl)-cyclohexanecarboxylic acid methyl ester (179617-84-6) + 4-(3,4-Dicyano-2,5-dihydroxy-phenyl)-cyclohexanecarboxylic acid methyl ester (179617-83-5)

Guidance literature:

With sulfuric acid; In water; isopropyl alcohol; at 20 - 30 ℃; for 10h; Yield given. Yields of byproduct given;

DOI:10.1016/0040-4020(96)00405-X

Reference yield: 97.0%

benzyl bromide (100-39-0) + 4-(3,4-Dicyano-2,5-dihydroxy-phenyl)-cyclohexanecarboxylic acid methyl ester (179617-83-5) → 4-(2,5-Bis-benzyloxy-3,4-dicyano-phenyl)-cyclohexanecarboxylic acid methyl ester (179617-85-7)

Guidance literature:

With potassium carbonate; In acetone; for 1h; Heating;

DOI:10.1016/0040-4020(96)00405-X

Reference yield:

4-(3,4-Dicyano-2,5-dihydroxy-phenyl)-cyclohexanecarboxylic acid methyl ester (179617-83-5) → 4(e)-(2,5-bis-benzyloxy-3,4-dicyano-phenyl)-cyclohexane-(a)-carbaldehyde (179617-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / K₂CO₃ / acetone / 1 h / Heating

2: 94 percent / diisobutylaluminium hydride / diethyl ether; CH₂Cl₂ / 1 h / -95 °C

With diisobutylaluminium hydride; potassium carbonate; In diethyl ether; dichloromethane; acetone;

DOI:10.1016/0040-4020(96)00405-X

upstream raw materials:

potassium cyanide

Downstream raw materials:

4-(2,5-Bis-benzyloxy-3,4-dicyano-phenyl)-cyclohexanecarboxylic acid methyl ester

4(e)-(2,5-bis-benzyloxy-3,4-dicyano-phenyl)-cyclohexane-(a)-carbaldehyde