2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-4-phenyl-1H-imidazole

Base Information

Chemical Name:2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-4-phenyl-1H-imidazole
CAS No.:1239957-35-7
Molecular Formula:C₃₁H₂₃Cl₃F₂N₂S
Molecular Weight:599.959
Hs Code.:

Synonyms:2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-4-phenyl-1H-imidazole

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Chemical Property of 2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-4-phenyl-1H-imidazole

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Technology Process of 2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-4-phenyl-1H-imidazole

There total 4 articles about 2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-4-phenyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1239957-34-6
4-bromo-2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

: 98-80-6
phenylboronic acid

: 1239957-35-7
2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-4-phenyl-1H-imidazole

Guidance literature:: With potassium phosphate; tris(o-methoxyphenyl)phosphine; palladium diacetate; In ethanol; water; Reflux;

Reference yield:

: 1239956-60-5
2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

: 1239957-35-7
2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-4-phenyl-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: bromine; sodium carbonate / dichloromethane; water / 0 °C

2: potassium phosphate / tris(o-methoxyphenyl)phosphine; palladium diacetate / ethanol; water / Reflux

With potassium phosphate; bromine; sodium carbonate; tris(o-methoxyphenyl)phosphine; palladium diacetate; In ethanol; dichloromethane; water; 2: Suzuki Coupling;

Reference yield:

: 1239963-77-9
5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2(3H)-thione

: 1239957-35-7
2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-4-phenyl-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 2 h

2: bromine; sodium carbonate / dichloromethane; water / 0 °C

3: potassium phosphate / tris(o-methoxyphenyl)phosphine; palladium diacetate / ethanol; water / Reflux

With potassium phosphate; bromine; sodium carbonate; potassium carbonate; tris(o-methoxyphenyl)phosphine; palladium diacetate; In ethanol; dichloromethane; water; acetone; 3: Suzuki Coupling;