4-oxo-pentanoic acid 2-[[5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester

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Chemical Name:4-oxo-pentanoic acid 2-[[5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester
CAS No.:356535-47-2
Molecular Formula:C₄₄H₄₆Cl₂N₉O₁₃PS
Molecular Weight:1042.85
Hs Code.:

4-oxo-pentanoic acid 2-[[5-(4-benzoylamino-2-oxo-2<i>H</i>-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester

Synonyms:4-oxo-pentanoic acid 2-[[5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester

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Chemical Property of 4-oxo-pentanoic acid 2-[[5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester

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Technology Process of 4-oxo-pentanoic acid 2-[[5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester

There total 3 articles about 4-oxo-pentanoic acid 2-[[5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 356535-42-7
C₆₅H₆₄Cl₂N₉O₁₅PS

: 356535-47-2
4-oxo-pentanoic acid 2-[[5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester

Guidance literature:: With dichloro-acetic acid; pyrrole; In dichloromethane; at 0 ℃; for 0.166667h;
DOI:10.1039/b208802a

Reference yield:

: C₃₇H₃₅N₃O₉P^(1-)

: 356535-47-2
4-oxo-pentanoic acid 2-[[5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: (PhO)2POCl; C₅H₅N / 20 °C

2: Cl₂CHCO₂H; pyrrole / CH₂Cl₂ / 20 °C

With pyridine; dichloro-acetic acid; pyrrole; chlorophosphoric acid diphenyl ester; In dichloromethane;
DOI:10.1016/S0040-4039(03)00322-8

Reference yield:

: 199436-66-3
2'-deoxy-6-O-(2,5-dichlorophenyl)-2-N-isobutyryl-3'-O-levulinylguanosine

: 356535-47-2
4-oxo-pentanoic acid 2-[[5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: (PhO)2POCl; C₅H₅N / 20 °C

2: Cl₂CHCO₂H; pyrrole / CH₂Cl₂ / 20 °C

With pyridine; dichloro-acetic acid; pyrrole; chlorophosphoric acid diphenyl ester; In dichloromethane;
DOI:10.1016/S0040-4039(03)00322-8