ethyl (2R,3R + 2S,3S)-3-(o-carbomethoxybenzamido)-6-phthalimidohexanoate-2,3-d2

Base Information

Chemical Name:ethyl (2R,3R + 2S,3S)-3-(o-carbomethoxybenzamido)-6-phthalimidohexanoate-2,3-d2
CAS No.:86146-70-5
Molecular Formula:C₂₅H₂₆N₂O₇
Molecular Weight:468.475
Hs Code.:

Synonyms:ethyl (2R,3R + 2S,3S)-3-(o-carbomethoxybenzamido)-6-phthalimidohexanoate-2,3-d2

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Chemical Property of ethyl (2R,3R + 2S,3S)-3-(o-carbomethoxybenzamido)-6-phthalimidohexanoate-2,3-d2

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Technology Process of ethyl (2R,3R + 2S,3S)-3-(o-carbomethoxybenzamido)-6-phthalimidohexanoate-2,3-d2

There total 6 articles about ethyl (2R,3R + 2S,3S)-3-(o-carbomethoxybenzamido)-6-phthalimidohexanoate-2,3-d2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 86146-69-2
ethyl (Z)-3-(o-carbomethoxybenzamido)-6-phthalimidohex-2-enoate

: 86146-70-5
ethyl (2R,3R + 2S,3S)-3-(o-carbomethoxybenzamido)-6-phthalimidohexanoate-2,3-d2

Guidance literature:: With deuterium; Wilkinson's catalyst; In ethanol; at 25 ℃; for 36h; under 21720.2 Torr;
DOI:10.1021/ja00354a046

Reference yield:

: 10314-06-4
4-phthalimidobutyryl chloride

: 86146-70-5
ethyl (2R,3R + 2S,3S)-3-(o-carbomethoxybenzamido)-6-phthalimidohexanoate-2,3-d2

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / 1.) Mg(OEt)2 / 1.) EtOH-CCl₄-Et₂O, 4 h, 2.) 25 deg C, 13 h

2: 82 percent / 10percent NH₄OH / diethyl ether / 0 deg C -> 10 deg C; 10 deg C , 90 min

3: 54 percent / NH₃ / ethanol / 15 h / 25 °C

4: 71 percent / pyridine / CHCl₃ / 12 h / 60 °C

5: 79 percent / D₂ / tris(triphenylphosphine)rhodium(III) chloride / ethanol / 36 h / 25 °C / 21720.2 Torr

With pyridine; ammonium hydroxide; ammonia; magnesium ethylate; deuterium; Wilkinson's catalyst; In diethyl ether; ethanol; chloroform;
DOI:10.1021/ja00354a046

Reference yield:

: 79595-57-6
ethyl 3-oxo-6-phthalimidohexanoate

: 86146-70-5
ethyl (2R,3R + 2S,3S)-3-(o-carbomethoxybenzamido)-6-phthalimidohexanoate-2,3-d2

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / NH₃ / ethanol / 15 h / 25 °C

2: 71 percent / pyridine / CHCl₃ / 12 h / 60 °C

3: 79 percent / D₂ / tris(triphenylphosphine)rhodium(III) chloride / ethanol / 36 h / 25 °C / 21720.2 Torr

With pyridine; ammonia; deuterium; Wilkinson's catalyst; In ethanol; chloroform;
DOI:10.1021/ja00354a046