2-chloro-N-(2-chloro-6-nitrobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide

Base Information

Chemical Name:2-chloro-N-(2-chloro-6-nitrobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide
CAS No.:1365992-84-2
Molecular Formula:C₁₉H₈Cl₂F₂N₄O₆
Molecular Weight:497.199
Hs Code.:

Synonyms:2-chloro-N-(2-chloro-6-nitrobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide

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Chemical Property of 2-chloro-N-(2-chloro-6-nitrobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide

Chemical Property:

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Technology Process of 2-chloro-N-(2-chloro-6-nitrobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide

There total 1 articles about 2-chloro-N-(2-chloro-6-nitrobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 159783-22-9
3,5-difluoropyridin-4-ylamine

: 50425-14-4
2-chloro-6-nitro-benzoic acid chloride

: 1365992-83-1
2-chloro-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide

: 1365992-84-2
2-chloro-N-(2-chloro-6-nitrobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide

Guidance literature:: 3,5-difluoropyridin-4-ylamine; 2-chloro-6-nitro-benzoic acid chloride; With pyridine; at 20 ℃; for 19h; Inert atmosphere;

With hydrogenchloride; In pyridine; water; at 20 ℃; for 0.5h; Sonicating;

Reference yield:

: 1365992-84-2
2-chloro-N-(2-chloro-6-nitrobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide

: 1365992-83-1
2-chloro-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide

Guidance literature:: 2-chloro-N-(2-chloro-6-nitrobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide; With methanol; sodium hydroxide; at 20 - 50 ℃; Inert atmosphere;

With hydrogenchloride; In methanol; water; pH=2 - 3;

Reference yield:

: 1365992-84-2
2-chloro-N-(2-chloro-6-nitrobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide

: 1365990-79-9
3-chloro-2-[7-fluoro-4-(6-methylpyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-2-yl]-benzonitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide; methanol / 20 - 50 °C / Inert atmosphere

1.2: pH 2 - 3

2.1: thionyl chloride / 18 h / Reflux

3.1: thiourea; pyridine / isopropyl alcohol / 6 h / Inert atmosphere; Reflux

3.2: Reflux

4.1: acetic acid; iron / 0.5 h / 100 °C

5.1: hydrogenchloride; sodium nitrite / acetonitrile; water / 0 °C

5.2: pH 6 - 7

5.3: 1.75 h / 60 - 70 °C

6.1: dihydrogen peroxide / methyltrioxorhenium(VII) / dichloromethane; water / 72 h / 20 °C / Inert atmosphere

7.1: trichlorophosphate / 1,2-dichloro-ethane / 16 h / 70 °C / Inert atmosphere

7.2: pH 6 - 7

8.1: trimethylsilyl bromide / propiononitrile / 20 - 50 °C / Inert atmosphere

9.1: caesium carbonate / 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

With pyridine; hydrogenchloride; methanol; thionyl chloride; trimethylsilyl bromide; dihydrogen peroxide; iron; caesium carbonate; acetic acid; thiourea; sodium hydroxide; sodium nitrite; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; methyltrioxorhenium(VII); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; isopropyl alcohol; acetonitrile; propiononitrile;