(S)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide

Base Information

• Chemical Name: (S)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide
• CAS No.: 1415582-05-6
• Molecular Formula: C₂₀H₁₈F₃IN₂O₅S
• Molecular Weight: 582.339

Synonyms:(S)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide

Chemical Property of (S)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide

There total 11 articles about (S)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2,3-dihydroxy-propyl)-cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodo-phenylamino)-benzofuran-7-yl]amide (1311401-03-2) → (R)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide (1415582-04-5) + (S)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide (1415582-05-6)

Guidance literature:

With Chiralpak AD-H; In methanol; hexane; isopropyl alcohol; at 25 ℃; Purification / work up; Resolution of racemate;

Reference yield:

2-fluro-4-iodoaniline (29632-74-4) → (R)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide (1415582-04-5) + (S)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide (1415582-05-6)

Guidance literature:

Multi-step reaction with 9 steps

1.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / 20 - 40 °C

2.1: sodium hydride / tetrahydrofuran / 2 h / 0 - 5 °C / Industry scale

2.2: 65 h / 0 - 20 °C / Industry scale

3.1: acetic acid

3.2: 0 - 40 °C

4.1: zinc; ammonium chloride / water; tetrahydrofuran / 2.33 h / 0 - 25 °C

5.1: dichloromethane / 20 - 40 °C

6.1: triethylamine / dmap / dichloromethane / 12 h / 0 - 40 °C

7.1: potassium trimethylsilonate / tetrahydrofuran / 4 h / 0 - 40 °C

8.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tetrahydrofuran / 20 °C

9.1: Chiralpak_.(R). AD-H_.(TM). / isopropyl alcohol; hexane; methanol / 25 °C / Resolution of racemate

With osmium(VIII) oxide; potassium trimethylsilonate; water; sodium hydride; ammonium chloride; acetic acid; 4-methylmorpholine N-oxide; triethylamine; lithium hexamethyldisilazane; zinc; dmap; In tetrahydrofuran; methanol; hexane; dichloromethane; water; isopropyl alcohol;

Reference yield:

1,2,3,5-tetrafluoro-4-nitrobenzene (314-41-0) → (R)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide (1415582-04-5) + (S)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide (1415582-05-6)

Guidance literature:

Multi-step reaction with 9 steps

1.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / 20 - 40 °C

2.1: sodium hydride / tetrahydrofuran / 2 h / 0 - 5 °C / Industry scale

2.2: 65 h / 0 - 20 °C / Industry scale

3.1: acetic acid

3.2: 0 - 40 °C

4.1: zinc; ammonium chloride / water; tetrahydrofuran / 2.33 h / 0 - 25 °C

5.1: dichloromethane / 20 - 40 °C

6.1: triethylamine / dmap / dichloromethane / 12 h / 0 - 40 °C

7.1: potassium trimethylsilonate / tetrahydrofuran / 4 h / 0 - 40 °C

8.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tetrahydrofuran / 20 °C

9.1: Chiralpak_.(R). AD-H_.(TM). / isopropyl alcohol; hexane; methanol / 25 °C / Resolution of racemate

With osmium(VIII) oxide; potassium trimethylsilonate; water; sodium hydride; ammonium chloride; acetic acid; 4-methylmorpholine N-oxide; triethylamine; lithium hexamethyldisilazane; zinc; dmap; In tetrahydrofuran; methanol; hexane; dichloromethane; water; isopropyl alcohol;

upstream raw materials:

2-fluro-4-iodoaniline

1,2,3,5-tetrafluoro-4-nitrobenzene

1,2,3,5-tetrafluorobenzene

(2-fluoro-4-iodo-phenyl)-(2,3,5-trifluoro-6-nitro-phenyl)-amine

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