6-(2-chloro-4-pyridyl)-3-methyl-2-methylthio-5-(3-(trifluoromethyl)phenyl)-(3H)-pyrimidin-4-one

Base Information

• Chemical Name: 6-(2-chloro-4-pyridyl)-3-methyl-2-methylthio-5-(3-(trifluoromethyl)phenyl)-(3H)-pyrimidin-4-one
• CAS No.: 534601-72-4
• Molecular Formula: C₁₈H₁₃ClF₃N₃OS
• Molecular Weight: 411.835

Synonyms:6-(2-chloro-4-pyridyl)-3-methyl-2-methylthio-5-(3-(trifluoromethyl)phenyl)-(3H)-pyrimidin-4-one

Chemical Property of 6-(2-chloro-4-pyridyl)-3-methyl-2-methylthio-5-(3-(trifluoromethyl)phenyl)-(3H)-pyrimidin-4-one

Chemical Property:

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Technology Process of 6-(2-chloro-4-pyridyl)-3-methyl-2-methylthio-5-(3-(trifluoromethyl)phenyl)-(3H)-pyrimidin-4-one

There total 2 articles about 6-(2-chloro-4-pyridyl)-3-methyl-2-methylthio-5-(3-(trifluoromethyl)phenyl)-(3H)-pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-chloro-4-pyridinenitrile (33252-30-1) + ethyl 3-trifluoromethylphenylacetate (331-33-9) + methyl thioisocyanate (556-61-6) + methyl iodide (74-88-4) → 6-(2-chloro-4-pyridyl)-3-methyl-2-methylthio-5-(3-(trifluoromethyl)phenyl)-(3H)-pyrimidin-4-one (534601-72-4)

Guidance literature:

2-chloro-4-pyridinenitrile; ethyl 3-trifluoromethylphenylacetate; With potassium tert-butylate; In N,N-dimethyl-formamide; tert-butyl alcohol; at 20 ℃; for 1.5h;

methyl thioisocyanate; In N,N-dimethyl-formamide; tert-butyl alcohol; at 20 ℃; for 1h;

methyl iodide; In N,N-dimethyl-formamide; tert-butyl alcohol; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2006.09.047

Reference yield:

→ 6-(2-chloro-4-pyridyl)-3-methyl-2-methylthio-5-(3-(trifluoromethyl)phenyl)-(3H)-pyrimidin-4-one (534601-72-4)

Guidance literature:

Reference yield:

6-(2-chloro-4-pyridyl)-3-methyl-2-methylthio-5-(3-(trifluoromethyl)phenyl)-(3H)-pyrimidin-4-one (534601-72-4) + SiO2 gel → 4-Chloro-6-(2-chloro-pyridin-4-yl)-2-methylthio-5-(3-(trifluoromethyl)-phenyl)pyrimidine (534601-71-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In hexane; ethyl acetate;

upstream raw materials:

2-chloro-4-pyridinenitrile

ethyl 3-trifluoromethylphenylacetate

methyl thioisocyanate

methyl iodide

Downstream raw materials:

4-Chloro-6-(2-chloro-pyridin-4-yl)-2-methylthio-5-(3-(trifluoromethyl)-phenyl)pyrimidine

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