331-33-9

Basic information

• Product Name: ETHYL 3-(TRIFLUOROMETHYL)PHENYLACETATE
• Synonyms: ETHYL 3-(TRIFLUOMETHYL)PHENYL ACETATE;ETHYL 3-(TRIFLUOROMETHYL)PHENYLACETATE;ethyl 2-(3-(trifluoromethyl)phenyl)acetate;REF DUPL: Ethyl 3-(trifluoromethyl)phenylacetate;3-[(Ethoxycarbonyl)methyl]benzotrifluoride, 3-(Trifluoromethyl)phenylacetic acid ethyl ester;Ethyl 2-(3-(trifluoromethyl)
• CAS NO: 331-33-9
• Molecular Formula: C₁₁H₁₁F₃O₂
• Molecular Weight: 232.2
• Mol File: 331-33-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 231.1°Cat760mmHg
• Flash Point: 66.9°C
• Appearance: /
• Density: 1.207g/cm³
• Vapor Pressure: 0.0636mmHg at 25°C
• Refractive Index: 1.451
• CAS DataBase Reference: ETHYL 3-(TRIFLUOROMETHYL)PHENYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 3-(TRIFLUOROMETHYL)PHENYLACETATE(331-33-9)
• EPA Substance Registry System: ETHYL 3-(TRIFLUOROMETHYL)PHENYLACETATE(331-33-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 331-33-9(Hazardous Substances Data)

Usage

General Description

ETHYL 3-(TRIFLUOROMETHYL)PHENYLACETATE is a chemical compound with the molecular formula C11H11F3O2. It is a colorless liquid with a fruity odor, commonly used as a flavoring agent in the food and beverage industry. This chemical is a derivative of phenylacetic acid, with a trifluoromethyl group attached to the phenyl ring. It is also used as an intermediate in the production of pharmaceuticals and agrochemicals. However, it is important to handle this compound with caution, as it may be harmful if swallowed, inhaled, or comes into contact with skin. Proper safety precautions and handling procedures should be followed when working with ETHYL 3-(TRIFLUOROMETHYL)PHENYLACETATE.

InChI:InChI=1/C11H11F3O2/c1-2-16-10(15)7-8-4-3-5-9(6-8)11(12,13)14/h3-6H,2,7H2,1H3

Upstream product

• 41023-25-0 ethyl α-bromo-(3-trifluoromethylphenyl)acetate 
• 64-17-5 ethanol 
• 351-35-9 3-(trifluoromethyl)phenylacetic acid 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 105-53-3 diethyl malonate 
• 1195-42-2 N-cyclohexylisopropylamine 
• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 
• 623-73-4 diazoacetic acid ethyl ester 
• 98-08-8 α,α,α-trifluorotoluene 

Downstream Products

• 87443-26-3 2-Hydroxy-1-methyl-5-phenyl-3-(3-trifluoromethyl-phenyl)-1H-pyridin-4-one 
• 41023-25-0 ethyl α-bromo-(3-trifluoromethylphenyl)acetate 
• 82129-70-2 1-(3-trifluoromethylphenyl)-2,4-heptanedione 
• 82129-51-9 1-(m-trifluoromethylphenyl)-pentan-2,4-dione 
• 1997-28-0 2-(3-trifluoromethyl-phenyl)-malonic acid diethyl ester 
• 534601-72-4 6-(2-chloro-4-pyridyl)-3-methyl-2-methylthio-5-(3-(trifluoromethyl)phenyl)-(3H)-pyrimidin-4-one 
• 82129-65-5 3-acetyl-1-methyl-5-(α,α,α-trifluoro-m-tolyl)-4(1H)-pyridinone 
• 82129-63-3 1-methyl-3-propionyl-5-(3-trifluoromethylphenyl)-4(1H)-pyridinone 
• 82129-69-9 3-butyryl-1-methyl-5-(3-trifluoromethylphenyl)-4(1H)-pyridinone 
• 1191107-34-2 ethyl 1-benzyl-4-(3-(trifluoromethyl)phenyl)piperidine-4-carboxylate 
• 773851-48-2 4-(3-trifluoromethyl-phenyl)-2H-isoxazol-5-one 
• 82129-64-4 1-(3-Trifluoromethyl-phenyl)-hexane-2,4-dione 
• 104173-36-6 2-<3-(Trifluormethyl)phenyl>acrylsaeure-ethylester 
• 712350-83-9 2-[2-carboxy-2-(3-trifluoromethyl-phenyl)-ethyl]-[1,3]oxazinane-3-carboxylic acid tert-butyl ester 

Relevant articles and documents

Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.

Mechanistic studies on gold-catalyzed direct arene c-h bond functionalization by carbene insertion: The coinage-metal effect

The catalytic functionalization of the Csp2-H bond of benzene by means of the insertion of the CHCO2Et group from ethyl diazoacetate (N2= CHCO2Et) has been studied with the series of coinage-metal complexes IPrMCl (IPr = 1,3-bis- (diisopropylphenyl)imidazol-2-ylidene) and NaBArF 4 (BArF 4 = tetrakis(3,5-bis(trifluoromethyl)phenyl)borate). For Cu and Ag, these examples constitute the first use of such metals toward this transformation, which also provides ethyl cyclohepta-2,4,6-trienecarboxylate as a byproduct from the so-called Buchner reaction. In the case of methyl-substituted benzenes, the reaction exclusively proceeds onto the aromatic ring, the Csp3-H bond remaining unreacted. A significant coinage-metal effect has been observed, since the gold catalyst favors the formation of the insertion product into the Csp2-H bond whereas copper and silver preferentially induce the formation of the cycloheptatriene derivative. Experimental studies and theoretical calculations have explained the observed selectivity in terms of the formation of a common Wheland intermediate, resembling an electrophilic aromatic substitution, from which the reaction pathway evolves into two separate routes to each product.

NOVEL TRPV3 MODULATORS

Disclosed herein are modulators of TRPV3 of formula (II): wherein G1, X1, X2, X3, X4, X5, G2, Ra, Rb, and u are as defined in the specification. Composition