3-(4-cyclopentyloxy-3-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole

Base Information

Chemical Name:3-(4-cyclopentyloxy-3-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole
CAS No.:1312793-94-4
Molecular Formula:C₁₉H₂₅N₃O₃
Molecular Weight:343.426
Hs Code.:

Synonyms:3-(4-cyclopentyloxy-3-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole

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Chemical Property of 3-(4-cyclopentyloxy-3-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole

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Technology Process of 3-(4-cyclopentyloxy-3-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole

There total 6 articles about 3-(4-cyclopentyloxy-3-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1312793-87-5
tert-butyl 4-(3-(4-cyclopentyloxy-3-methoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate

: 1312793-94-4
3-(4-cyclopentyloxy-3-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole

Guidance literature:: tert-butyl 4-(3-(4-cyclopentyloxy-3-methoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 0 - 25 ℃; for 6h;

With sodium hydrogencarbonate;
DOI:10.1016/j.ejmech.2011.03.031

Reference yield:

: 1016821-23-0
C₁₃H₁₈N₂O₃

: 1312793-94-4
3-(4-cyclopentyloxy-3-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

1.2: 3.5 h / 0 - 30 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 10 h / 110 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 25 °C

With dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.03.031

Reference yield:

: 1016867-30-3
C₁₃H₁₅NO₂

: 1312793-94-4
3-(4-cyclopentyloxy-3-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 18 h / 0 °C / Reflux

2.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

2.2: 3.5 h / 0 - 30 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide / 10 h / 110 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 25 °C

With hydroxylamine hydrochloride; sodium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.03.031