trichloroethyl 2α-(chloromethyl)-2β-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate 1S-oxide

Base Information

• Chemical Name: trichloroethyl 2α-(chloromethyl)-2β-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate 1S-oxide
• CAS No.: 138976-44-0
• Molecular Formula: C₁₈H₁₈Cl₄N₂O₆S
• Molecular Weight: 532.229
• Mol file: 138976-44-0.mol

Synonyms:trichloroethyl 2α-(chloromethyl)-2β-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate 1S-oxide

Chemical Property of trichloroethyl 2α-(chloromethyl)-2β-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate 1S-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trichloroethyl 2α-(chloromethyl)-2β-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate 1S-oxide

There total 4 articles about trichloroethyl 2α-(chloromethyl)-2β-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate 1S-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.7%

trichloroethyl 2β-(chloromethyl)-2α-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate 1R-oxide (138976-43-9) → trichloroethyl 2α-(chloromethyl)-2β-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate 1S-oxide (138976-44-0)

Guidance literature:

In toluene; for 0.333333h; Heating;

DOI:10.1016/0223-5234(91)90005-8

Reference yield:

trichloroethyl 2β-(chloromethyl)-2α-methyl-6β-(N-nitrosophenoxyacetamido)-penam-3α-carboxylate (138976-41-7) → trichloroethyl 2α-(chloromethyl)-2β-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate 1S-oxide (138976-44-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 98.7 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / 0 °C

2: 90 percent / H₂ / 10percent Pd/C / ethyl acetate / 1.5 h / 310.4 Torr

3: 46.7 percent / toluene / 0.33 h / Heating

With hydrogen; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate; toluene;

DOI:10.1016/0223-5234(91)90005-8

Reference yield:

trichloroethyl 2β-(chloromethyl)-2α-methyl-6β-(N-nitrosophenoxyacetamido)-penam-3α-carboxylate 1R-oxide (138976-42-8) → trichloroethyl 2α-(chloromethyl)-2β-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate 1S-oxide (138976-44-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / H₂ / 10percent Pd/C / ethyl acetate / 1.5 h / 310.4 Torr

2: 46.7 percent / toluene / 0.33 h / Heating

With hydrogen; palladium on activated charcoal; In ethyl acetate; toluene;

DOI:10.1016/0223-5234(91)90005-8

upstream raw materials:

trichloroethyl 2β-(chloromethyl)-2α-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate 1R-oxide

trichloroethyl 2β-(chloromethyl)-2α-methyl-6β-(N-nitrosophenoxyacetamido)-penam-3α-carboxylate

trichloroethyl 2β-(chloromethyl)-2α-methyl-6β-(N-nitrosophenoxyacetamido)-penam-3α-carboxylate 1R-oxide

trichloroethyl 2β-(chloromethyl)-2α-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate

Downstream raw materials:

trichloroethyl 2α-(chloromethyl)-2β-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate

2α-<(1-methyl-1,2,3,4-tetrazol-5-yl)thiomethyl>-2β-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylic acid 1β-oxide

trichloroethyl 2α-<(1-methyl-1,2,3,4-tetrazol-5-yl)thiomethyl>-2β-methyl-6β-(phenoxyacetamido)penam-3α-carboxylate 1β-oxide

2α-<(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl>-2β-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylic acid