(R)-dimethyl-2-((S)-3-azido-2-(tert-butoxycarbonylamino)-N-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl)benzyl)propanamido)succinate

Base Information

Chemical Name:(R)-dimethyl-2-((S)-3-azido-2-(tert-butoxycarbonylamino)-N-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl)benzyl)propanamido)succinate
CAS No.:1414916-01-0
Molecular Formula:C₂₆H₃₂N₆O₇S
Molecular Weight:572.642
Hs Code.:

Synonyms:(R)-dimethyl-2-((S)-3-azido-2-(tert-butoxycarbonylamino)-N-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl)benzyl)propanamido)succinate

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Chemical Property of (R)-dimethyl-2-((S)-3-azido-2-(tert-butoxycarbonylamino)-N-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl)benzyl)propanamido)succinate

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Technology Process of (R)-dimethyl-2-((S)-3-azido-2-(tert-butoxycarbonylamino)-N-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl)benzyl)propanamido)succinate

There total 6 articles about (R)-dimethyl-2-((S)-3-azido-2-(tert-butoxycarbonylamino)-N-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl)benzyl)propanamido)succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39895-56-2
4-hydroxymethyl-benzylamine

: 1414916-01-0
(R)-dimethyl-2-((S)-3-azido-2-(tert-butoxycarbonylamino)-N-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl)benzyl)propanamido)succinate

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 6.5 h / 0 - 20 °C / Inert atmosphere

2: manganese(IV) oxide / tetrahydrofuran / Inert atmosphere

3: sodium cyanoborohydride / methanol / 4 h / 20 °C / Inert atmosphere

4: dichloromethane / 20 °C

5: triethylsilane; trifluoroacetic acid / dichloromethane / 3 h / 20 °C

6: isopropyl alcohol; N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C

With triethylsilane; manganese(IV) oxide; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm301058f

Reference yield:

: C₂₇H₃₆N₆O₈S*C₃H₃F₃O

: 1414916-01-0
(R)-dimethyl-2-((S)-3-azido-2-(tert-butoxycarbonylamino)-N-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl)benzyl)propanamido)succinate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; isopropyl alcohol; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1021/jm301058f

Reference yield:

: 1414915-97-1
(R)-dimethyl-2-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl)benzylamino)succinate

: 1414916-01-0
(R)-dimethyl-2-((S)-3-azido-2-(tert-butoxycarbonylamino)-N-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl)benzyl)propanamido)succinate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 20 °C

2: triethylsilane; trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3: isopropyl alcohol; N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C

With triethylsilane; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm301058f