(R)-dimethyl-2-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl)benzylamino)succinate

Base Information

Chemical Name:(R)-dimethyl-2-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl)benzylamino)succinate
CAS No.:1414915-97-1
Molecular Formula:C₂₄H₃₂N₂O₇S
Molecular Weight:492.593
Hs Code.:

Synonyms:(R)-dimethyl-2-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl)benzylamino)succinate

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Chemical Property of (R)-dimethyl-2-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl)benzylamino)succinate

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Technology Process of (R)-dimethyl-2-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl)benzylamino)succinate

There total 4 articles about (R)-dimethyl-2-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl)benzylamino)succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39895-56-2
4-hydroxymethyl-benzylamine

: 1414915-97-1
(R)-dimethyl-2-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl)benzylamino)succinate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 6.5 h / 0 - 20 °C / Inert atmosphere

2: manganese(IV) oxide / tetrahydrofuran / Inert atmosphere

3: sodium cyanoborohydride / methanol / 4 h / 20 °C / Inert atmosphere

With manganese(IV) oxide; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;
DOI:10.1021/jm301058f

Reference yield:

: 1414915-83-5
4-((4-methoxy-2,3,6-trimethylphenylsulfonyl)aminomethyl)benzaldehyde

: 14358-33-9,32213-95-9,69630-50-8
dimethyl (R)-2-aminobutanedioate hydrochloride

: 1414915-97-1
(R)-dimethyl-2-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl)benzylamino)succinate

Guidance literature:: With sodium cyanoborohydride; In methanol; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm301058f

Reference yield:

: 56-91-7
p-aminomethylbenzoic acid

: 1414915-97-1
(R)-dimethyl-2-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl)benzylamino)succinate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Reflux

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 6.5 h / 0 - 20 °C / Inert atmosphere

3: manganese(IV) oxide / tetrahydrofuran / Inert atmosphere

4: sodium cyanoborohydride / methanol / 4 h / 20 °C / Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;
DOI:10.1021/jm301058f