Bis(4-methoxyphenyl)chlorophosphine

Base Information

• Chemical Name: Bis(4-methoxyphenyl)chlorophosphine
• CAS No.: 13685-30-8
• Molecular Formula: C14H14 Cl O2 P
• Molecular Weight: 280.691
• Hs Code.: 2909309090
• European Community (EC) Number: 634-361-6
• DSSTox Substance ID: DTXSID90402630
• Nikkaji Number: J1.877.809B
• Wikidata: Q82206059
• Mol file: 13685-30-8.mol

Synonyms:BIS(4-METHOXYPHENYL)CHLOROPHOSPHINE;13685-30-8;Chlorobis(4-methoxyphenyl)phosphine;Chloro-bis(4-methoxyphenyl)phosphane;Phosphinous chloride, P,P-bis(4-methoxyphenyl)-;SCHEMBL668577;DTXSID90402630;MFCD04972301;Bis(4-methoxyphenyl)chlorophosphine, 85%;Bis(4-methoxyphenyl)chlorophosphine, 95%;FT-0732477;J-006927

Chemical Property of Bis(4-methoxyphenyl)chlorophosphine

Chemical Property:

• Vapor Pressure: 5.16E-06mmHg at 25°C
• Melting Point: 61-64℃
• Boiling Point: 140℃/1.5mm
• Flash Point: 140℃/1.5mm
• PSA: 32.05000
• Density: g/cm³
• LogP: 3.29030
• Sensitive.: Moisture Sensitive
• Water Solubility.: Reacts with water.
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 280.0419944
• Heavy Atom Count: 18
• Complexity: 212

Purity/Quality:

98% ^*data from raw suppliers

Chlorobis(4-methoxyphenyl)phosphine, 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)P(C2=CC=C(C=C2)OC)Cl
• Uses: Chlorobis(4-methoxyphenyl)phosphine is used an pharmaceutical intermediate.

Technology Process of Bis(4-methoxyphenyl)chlorophosphine

There total 7 articles about Bis(4-methoxyphenyl)chlorophosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

bis(4-methoxyphenyl)phosphine oxide (15754-51-5) → chlorobis(4-methoxyphenyl)phosphane (13685-30-8)

Guidance literature:

With acetyl chloride; In tetrahydrofuran; at 25 ℃; for 12h; Inert atmosphere; Sealed tube;

Reference yield: 45.0%

→ chlorobis(4-methoxyphenyl)phosphane (13685-30-8)

Guidance literature:

Reference yield: 33.0%

1-bromo-4-methoxy-benzene (104-92-7) → chlorobis(4-methoxyphenyl)phosphane (13685-30-8)

Guidance literature:

1-bromo-4-methoxy-benzene; With magnesium; In diethyl ether; at 20 ℃; Inert atmosphere;

With diethylphosphoramidous dichloride; In diethyl ether; for 2h; Inert atmosphere; Reflux;

DOI:10.1002/anie.201208082

upstream raw materials:

bis(4-methoxyphenyl)phosphine oxide

(diethylamino)bis(4-methoxyphenyl)phosphane

1-bromo-4-methoxy-benzene

4-methoxyphenyl magnesium bromide

Downstream raw materials:

bis(4-methoxyphenyl)phosphine

C₁₇H₂₁O₃P

ethoxy bis-(4-methoxyphenyl)phosphine

C₁₉H₂₅O₃P