Bis(4-methoxyphenyl)phosphine oxide

Base Information

• Chemical Name: Bis(4-methoxyphenyl)phosphine oxide
• CAS No.: 15754-51-5
• Molecular Formula: C14H15O3P
• Molecular Weight: 262.245
• Mol file: 15754-51-5.mol

Synonyms:di(4-methoxyphenyl)phosphine oxide;di(p-methoxyphenyl)phosphinous acid;di-p-anisylphosphine oxide;bis(p-methoxyphenyl)phosphine oxide;Bis(4-methoxyphenyl)phosphonic acid;Bis(4-methoxyphenyl)phosphine oxide;Phosphine oxide,bis(4-methoxyphenyl);di(p-methoxyphenyl)phosphine oxide;

Chemical Property of Bis(4-methoxyphenyl)phosphine oxide

Chemical Property:

• Melting Point: 124-125 °C
• Boiling Point: 401.0±55.0 °C(Predicted)
• PSA: 59.00000
• LogP: 2.21430
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Bis(4-methoxyphenyl)phosphine oxide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Bis(4-methoxyphenyl)phosphine oxide

There total 12 articles about Bis(4-methoxyphenyl)phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

phosphonic acid diethyl ester (762-04-9) + 4-methoxyphenyl magnesium bromide (13139-86-1) → bis(4-methoxyphenyl)phosphine oxide (15754-51-5)

Guidance literature:

phosphonic acid diethyl ester; 4-methoxyphenyl magnesium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 2.33333h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; tert-butyl methyl ether; water; at 0 ℃; for 0.416667h;

DOI:10.1007/s11164-018-3403-3

Reference yield: 91.0%

Tris(4-methoxyphenyl)phosphine oxide (803-17-8) → bis(4-methoxyphenyl)phosphine oxide (15754-51-5)

Guidance literature:

With sodium hydride; lithium iodide; In tetrahydrofuran; at 60 ℃; for 13h; Inert atmosphere;

DOI:10.1039/c8cc00289d

Reference yield: 89.0%

1-bromo-4-methoxy-benzene (104-92-7) → bis(4-methoxyphenyl)phosphine oxide (15754-51-5)

Guidance literature:

1-bromo-4-methoxy-benzene; With magnesium; In tetrahydrofuran; at 0 - 20 ℃; for 20.25h; Inert atmosphere;

With phosphonic acid diethyl ester; In tetrahydrofuran; at 0 - 20 ℃; for 20.25h; Inert atmosphere;

DOI:10.1002/adsc.201800723

upstream raw materials:

1-bromo-4-methoxy-benzene

phosphonic acid diethyl ester

4-methoxyphenyl magnesium bromide

Diethyl phosphonate

Downstream raw materials:

bis(4-methoxyphenyl)phosphinic acid

chlorobis(4-methoxyphenyl)phosphane

(R)-7-di(p-methoxyphenyl)phosphinyl-7'-trifluoromethanesulfonyloxy-1,1'-spirobiindane

(1R,2R,3R,4R)-3,4-Bis-{2-[bis-(4-methoxy-phenyl)-phosphinoyl]-phenyl}-cyclobutane-1,2-dicarboxylic acid diethyl ester

Refernces

• 1、 Li, Xue-Hong,Gong, Jun-Fang,Song, Mao-Ping. "Microwave-Assisted Ruthenium- and Rhodium-Catalyzed Couplings of α-Amino Acid Ester-Derived Phosphinamides with Alkynes". supporting information. . Retrieved 2021/12/23.
• 2、 Chen, Yuan,Fang, Siqiang,Pan, Jianke,Ren, Xiaoyu,Tan, Jian-Ping,Wang, Tianli,Zhang, Hongkui. "Enantiodivergent Kinetic Resolution of 1,1′-Biaryl-2,2′-Diols and Amino Alcohols by Dipeptide-Phosphonium Salt Catalysis Inspired by the Atherton–Todd Reaction". supporting information. p. 14921 - 14930. Retrieved 2021/05/10.