17β-<(tert-butyldimethylsilyl)oxy>-5,5-(ethylenedioxy)-2,5-seco-3,4-dinorandrostan-2-yl thiobenzoate

Base Information

Chemical Name:17β-<(tert-butyldimethylsilyl)oxy>-5,5-(ethylenedioxy)-2,5-seco-3,4-dinorandrostan-2-yl thiobenzoate
CAS No.:87136-10-5
Molecular Formula:C₃₂H₅₀O₄SSi
Molecular Weight:558.898
Hs Code.:

Synonyms:17β-<(tert-butyldimethylsilyl)oxy>-5,5-(ethylenedioxy)-2,5-seco-3,4-dinorandrostan-2-yl thiobenzoate

Suppliers and Price of 17β-<(tert-butyldimethylsilyl)oxy>-5,5-(ethylenedioxy)-2,5-seco-3,4-dinorandrostan-2-yl thiobenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 17β-<(tert-butyldimethylsilyl)oxy>-5,5-(ethylenedioxy)-2,5-seco-3,4-dinorandrostan-2-yl thiobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 17β-<(tert-butyldimethylsilyl)oxy>-5,5-(ethylenedioxy)-2,5-seco-3,4-dinorandrostan-2-yl thiobenzoate

There total 6 articles about 17β-<(tert-butyldimethylsilyl)oxy>-5,5-(ethylenedioxy)-2,5-seco-3,4-dinorandrostan-2-yl thiobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 98-91-9
thiobenzoic acid

: 87116-09-4
17β-<(tert-butyldimethylsilyl)oxy>-5,5-(ethylenedioxy)-2-hydroxy-2,5-seco-3,4-dinorandrostane

: 87136-10-5
17β-<(tert-butyldimethylsilyl)oxy>-5,5-(ethylenedioxy)-2,5-seco-3,4-dinorandrostan-2-yl thiobenzoate

Guidance literature:: With diisopropyl azodicarboxylate-triphenylphosphine; In tetrahydrofuran; 1.) 0 deg C 90 min, 2.) 25 deg C, 1 h;
DOI:10.1021/jo00170a055

Reference yield:

: 58-22-0
testosterone

: 87136-10-5
17β-<(tert-butyldimethylsilyl)oxy>-5,5-(ethylenedioxy)-2,5-seco-3,4-dinorandrostan-2-yl thiobenzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / H₂O₂, NaOH / methanol / 0 °C

2: 93 percent / TsNHNH₂ / acetic acid

3: 1.) potassium tert-butoxide, 2.) TsOH / 1.) t-BuOH, 2.) benzene

4: 1.) imidazole, 2.) H₂ / 2.) Pd/BaSO₄ / 1.) DMF

5: 1.) O₃, 2.) NaBH₄ / 1.) CH₃OH, 2.) CH₂Cl₂, -78 deg C

6: 56 percent / diisopropyl azodicarboxylate-triphenylphosphine complex / tetrahydrofuran / 1.) 0 deg C 90 min, 2.) 25 deg C, 1 h

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; potassium tert-butylate; diisopropyl azodicarboxylate-triphenylphosphine; hydrogen; dihydrogen peroxide; toluene-4-sulfonic acid; ozone; toluene-4-sulfonic acid hydrazide; Pd-BaSO₄; In tetrahydrofuran; methanol; acetic acid;
DOI:10.1021/jo00170a055

Reference yield:

: 17541-44-5
17β-hydroxy-5-oxo-4,5-seco-androst-3-yne

: 87136-10-5
17β-<(tert-butyldimethylsilyl)oxy>-5,5-(ethylenedioxy)-2,5-seco-3,4-dinorandrostan-2-yl thiobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) potassium tert-butoxide, 2.) TsOH / 1.) t-BuOH, 2.) benzene

2: 1.) imidazole, 2.) H₂ / 2.) Pd/BaSO₄ / 1.) DMF

3: 1.) O₃, 2.) NaBH₄ / 1.) CH₃OH, 2.) CH₂Cl₂, -78 deg C

4: 56 percent / diisopropyl azodicarboxylate-triphenylphosphine complex / tetrahydrofuran / 1.) 0 deg C 90 min, 2.) 25 deg C, 1 h

With 1H-imidazole; sodium tetrahydroborate; potassium tert-butylate; diisopropyl azodicarboxylate-triphenylphosphine; hydrogen; toluene-4-sulfonic acid; ozone; Pd-BaSO₄; In tetrahydrofuran;
DOI:10.1021/jo00170a055