17541-44-5

Upstream product

• 51154-10-0 17β-hydroxy-4ξ,5-oxido-5ξ-androstan-3-one 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 64-19-7 acetic acid 

Downstream Products

• 87136-10-5 17β-<(tert-butyldimethylsilyl)oxy>-5,5-(ethylenedioxy)-2,5-seco-3,4-dinorandrostan-2-yl thiobenzoate 
• 142004-75-9 Benzoic acid (1S,3aS,3bS,8S,10aR,10bS,12aS)-8-(tert-butyl-dimethyl-silanyloxy)-10a,12a-dimethyl-6-oxo-hexadecahydro-6a-aza-benzo[3,4]cyclohepta[1,2-e]inden-1-yl ester 
• 142004-74-8 Benzoic acid (1S,3aS,3bS,8R,10aR,10bS,12aS)-8-(tert-butyl-dimethyl-silanyloxy)-10a,12a-dimethyl-6-oxo-hexadecahydro-6a-aza-benzo[3,4]cyclohepta[1,2-e]inden-1-yl ester 
• 142004-89-5 3ξ,17β-dihydroxy-4-iodo-5-aza-4,5-seco-B-homoandrostan-6-one 3-tert-butyldimethylsilyl ether, 17-benzoate 
• 142004-84-0 3,4-epoxy-17β-hydroxy-5-aza-4,5-seco-B-homoandrostan-6-one benzoate 
• 142004-80-6 Benzoic acid (3S,3aS,5aS,6R,9aR,9bS)-6-but-3-enyl-7-[(E)-hydroxyimino]-3a,6-dimethyl-dodecahydro-cyclopenta[a]naphthalen-3-yl ester 
• 142004-90-8 17β-hydroxy-5-aza-B-homoandrost-3-en-6-one benzoate 
• 142004-82-8 17β-hydroxy-5-aza-4,5-seco-B-homoandrost-3-en-6-one benzoate 
• 142004-79-3 Benzoic acid (3S,3aS,5aS,6R,9aS,9bS)-6-but-3-enyl-3a,6-dimethyl-7-oxo-dodecahydro-cyclopenta[a]naphthalen-3-yl ester 
• 138415-93-7 Benzoic acid (1S,3aS,3bS,8S,10aR,10bS,12aS)-10a,12a-dimethyl-6-oxo-8-(toluene-4-sulfonyloxy)-hexadecahydro-6a-aza-benzo[3,4]cyclohepta[1,2-e]inden-1-yl ester 
• 138415-92-6 Benzoic acid (1S,3aS,3bS,8R,10aR,10bS,12aS)-10a,12a-dimethyl-6-oxo-8-(toluene-4-sulfonyloxy)-hexadecahydro-6a-aza-benzo[3,4]cyclohepta[1,2-e]inden-1-yl ester 
• 138415-97-1 3β-(chloromethyl)-17β-hydroxy-5-aza-A-nor-B-homoandrostan-6-one benzoate 
• 138415-96-0 3α-(chloromethyl)-17β-hydroxy-5-aza-A-nor-B-homoandrostan-6-one benzoate 
• 138415-99-3 Benzoic acid (1R,3aR,3bS,5aS,6S,8aS,8bS)-1-hydroxymethyl-3a,5a-dimethyl-11-oxo-hexadecahydro-11a-aza-indeno[5,4-e]azulen-6-yl ester 

Relevant academic research and scientific papers

A Mild and Efficient Degradation of Ring A of Steroids

17-β-acetoxy-4,5-secoandrost-3-yn-5-one and 4,5-secopregn-3-yne-5,20-dione, readily available by Eschenmoser-Tanabe fragmentaton, have been rearranged to corresponding 2-ynes, which were cleaved to afford 2,5-seco-3,4-dinor-derivatives in excellent overall yield.The release of toluene-p-sulphinic acid during the fragmentation step can lead to the acetylation sulphinylation of an extraneous hydroxy-group.The active sulphinylating species is evidently p-tolyl toluene-p-sulphinyl sulphone.