2-(2-chloroethyl)-3,4-dihydro-4-methyl-7-phenylpyrido<3,2-f>-1,4-oxazepine-5(2H)-thione

Base Information

Chemical Name:2-(2-chloroethyl)-3,4-dihydro-4-methyl-7-phenylpyrido<3,2-f>-1,4-oxazepine-5(2H)-thione
CAS No.:117450-10-9
Molecular Formula:C₁₇H₁₇ClN₂OS
Molecular Weight:332.854
Hs Code.:

Synonyms:2-(2-chloroethyl)-3,4-dihydro-4-methyl-7-phenylpyrido<3,2-f>-1,4-oxazepine-5(2H)-thione

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Chemical Property of 2-(2-chloroethyl)-3,4-dihydro-4-methyl-7-phenylpyrido<3,2-f>-1,4-oxazepine-5(2H)-thione

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Technology Process of 2-(2-chloroethyl)-3,4-dihydro-4-methyl-7-phenylpyrido<3,2-f>-1,4-oxazepine-5(2H)-thione

There total 6 articles about 2-(2-chloroethyl)-3,4-dihydro-4-methyl-7-phenylpyrido<3,2-f>-1,4-oxazepine-5(2H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 117450-12-1
2-(2-chloroethyl)-3,4-dihydro-4-methyl-7-phenylpyrido<3,2-f>-1,4-oxazepin-5(2H)-one

: 117450-10-9
2-(2-chloroethyl)-3,4-dihydro-4-methyl-7-phenylpyrido<3,2-f>-1,4-oxazepine-5(2H)-thione

Guidance literature:: With Lawessons reagent; In toluene; 1a) reflux, 4 h, 1b) r.t., overnight;
DOI:10.1021/jm00129a026

Reference yield:

: 13220-33-2,99445-21-3
1-methyl-3-pyrrolidinol

: 117450-10-9
2-(2-chloroethyl)-3,4-dihydro-4-methyl-7-phenylpyrido<3,2-f>-1,4-oxazepine-5(2H)-thione

Guidance literature:: Multi-step reaction with 3 steps

1: 97 g / NaH / tetrahydrofuran / 6 h / Heating

2: 1) thionyl chloride, 2) diisopropylethylamine / 1) r.t., 10 min, 2) CH₂Cl₂

3: 64 percent / 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane 2,4-disulfide / toluene / 1a) reflux, 4 h, 1b) r.t., overnight

With Lawessons reagent; thionyl chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; toluene;
DOI:10.1021/jm00129a026

Reference yield:

: 10177-08-9
1,2-dihydro-2-oxo-5-phenyl-3-pyridinecarboxylic acid

: 117450-10-9
2-(2-chloroethyl)-3,4-dihydro-4-methyl-7-phenylpyrido<3,2-f>-1,4-oxazepine-5(2H)-thione

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / phenylphosphonic dichloride / 2 h / 135 °C

2: 97 g / NaH / tetrahydrofuran / 6 h / Heating

3: 1) thionyl chloride, 2) diisopropylethylamine / 1) r.t., 10 min, 2) CH₂Cl₂

4: 64 percent / 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane 2,4-disulfide / toluene / 1a) reflux, 4 h, 1b) r.t., overnight

With Lawessons reagent; P,P-dichlorophenylphosphine oxide; thionyl chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; toluene;
DOI:10.1021/jm00129a026