(S)-(-)-N-(1,3-benzo-dioxol-5-yl)-2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetamide

Base Information

Chemical Name:(S)-(-)-N-(1,3-benzo-dioxol-5-yl)-2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetamide
CAS No.:1450829-18-1
Molecular Formula:C₂₀H₁₉N₃O₄
Molecular Weight:365.389
Hs Code.:

Synonyms:(S)-(-)-N-(1,3-benzo-dioxol-5-yl)-2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetamide

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Chemical Property of (S)-(-)-N-(1,3-benzo-dioxol-5-yl)-2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetamide

Chemical Property:

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Technology Process of (S)-(-)-N-(1,3-benzo-dioxol-5-yl)-2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetamide

There total 4 articles about (S)-(-)-N-(1,3-benzo-dioxol-5-yl)-2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52239-91-5
4-methyl-6-phenyl-4,5-dihydropyridazin-3(2H)-one

: 1450829-13-6
(R)-(+)-N-(4-bromophenyl)-2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetamide

: 1450829-18-1
(S)-(-)-N-(1,3-benzo-dioxol-5-yl)-2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetonitrile / Reflux

2.1: sodium hydroxide / water / 80 °C

2.2: Cooling

3.1: triethylamine / tetrahydrofuran / 0.5 h / -5 °C

3.2: 0 °C

4.1: tetrahydrofuran / 12 h / 20 °C

5.1: Lux Amylose-2 column / acetonitrile; isopropyl alcohol / 40 °C / Resolution of racemate

With potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; water; isopropyl alcohol; acetonitrile;
DOI:10.1002/chir.22162

Reference yield:

: 1450829-12-5
(+/-)-N-(1,3-benzo-dioxol-5-yl)-2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetamide

: 1450829-13-6
(R)-(+)-N-(4-bromophenyl)-2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetamide

: 1450829-18-1
(S)-(-)-N-(1,3-benzo-dioxol-5-yl)-2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetamide

Guidance literature:: With Lux Amylose-2 column; In isopropyl alcohol; acetonitrile; at 40 ℃; Reagent/catalyst; Solvent; Resolution of racemate;
DOI:10.1002/chir.22162

Reference yield:

: 1450829-08-9
(+/-)-ethyl 2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetate

: 1450829-13-6
(R)-(+)-N-(4-bromophenyl)-2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetamide

: 1450829-18-1
(S)-(-)-N-(1,3-benzo-dioxol-5-yl)-2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water / 80 °C

1.2: Cooling

2.1: triethylamine / tetrahydrofuran / 0.5 h / -5 °C

2.2: 0 °C

3.1: tetrahydrofuran / 12 h / 20 °C

4.1: Lux Amylose-2 column / acetonitrile; isopropyl alcohol / 40 °C / Resolution of racemate

With triethylamine; sodium hydroxide; In tetrahydrofuran; water; isopropyl alcohol; acetonitrile;
DOI:10.1002/chir.22162