(1S,2S)-[1-hydroxymethyl-2-methoxy-4-(4-nitro-phenoxy)-butyl]carbamic acid tert-butyl ester

Base Information

Chemical Name:(1S,2S)-[1-hydroxymethyl-2-methoxy-4-(4-nitro-phenoxy)-butyl]carbamic acid tert-butyl ester
CAS No.:1052273-51-4
Molecular Formula:C₁₇H₂₆N₂O₇
Molecular Weight:370.403
Hs Code.:

Synonyms:(1S,2S)-[1-hydroxymethyl-2-methoxy-4-(4-nitro-phenoxy)-butyl]carbamic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S)-[1-hydroxymethyl-2-methoxy-4-(4-nitro-phenoxy)-butyl]carbamic acid tert-butyl ester

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Technology Process of (1S,2S)-[1-hydroxymethyl-2-methoxy-4-(4-nitro-phenoxy)-butyl]carbamic acid tert-butyl ester

There total 1 articles about (1S,2S)-[1-hydroxymethyl-2-methoxy-4-(4-nitro-phenoxy)-butyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1052273-50-3
(2S,3S)-2-tert-butoxycarbonylamino-3-methoxy-5-(4-nitrophenoxy)pentanoic acid methyl ester

: 1052273-51-4
(1S,2S)-[1-hydroxymethyl-2-methoxy-4-(4-nitro-phenoxy)-butyl]carbamic acid tert-butyl ester

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1039/b803310b

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 1052273-51-4
(1S,2S)-[1-hydroxymethyl-2-methoxy-4-(4-nitro-phenoxy)-butyl]carbamic acid tert-butyl ester

: 1052273-52-5
(1S,2S)-[2-methoxy-4-(4-nitro-phenoxy)-1-triisopropylsilanyloxymethyl-butyl]carbamic acid tert-butyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 4h;
DOI:10.1039/b803310b

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 1052273-51-4
(1S,2S)-[1-hydroxymethyl-2-methoxy-4-(4-nitro-phenoxy)-butyl]carbamic acid tert-butyl ester

: 75-03-6
ethyl iodide

: C₂₁H₃₄N₂O₇

: 1052273-53-6
(1S,2S)-ethyl-[2-methoxy-4-(4-nitro-phenoxy)-1-triisopropylsilanyloxymethyl-butyl]carbamic acid tert-butyl ester

Guidance literature:: triisopropylsilyl chloride; (1S,2S)-[1-hydroxymethyl-2-methoxy-4-(4-nitro-phenoxy)-butyl]carbamic acid tert-butyl ester; With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

With 18-crown-6 ether; potassium hydride; In tetrahydrofuran; at -20 ℃; for 0.166667h;

ethyl iodide; In tetrahydrofuran; at -20 ℃; for 3h;
DOI:10.1039/b803310b