Methionyl-Tyrosine

Base Information

• Chemical Name: Methionyl-Tyrosine
• CAS No.: 13589-04-3
• Molecular Formula: C14H20 N2 O4 S
• Molecular Weight: 312.39
• Hs Code.: 2930909090
• DSSTox Substance ID: DTXSID10874592
• Nikkaji Number: J81.650G
• Wikidata: Q27141932
• Metabolomics Workbench ID: 78914
• Mol file: 13589-04-3.mol

Synonyms:H-MET-TYR-OH;13589-04-3;Methionyl-Tyrosine;met-tyr;L-methionyl-L-tyrosine;L-Met-L-Tyr;L-Methionyl-L-tyrosin;N-L-Methionyl-L-tyrosine;SCHEMBL7609995;CHEBI:73615;DTXSID10874592;(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid;MY;MFCD00037186;AKOS010408834;BS-26562;CS-0372495;E82765;Q27141932;M-Y

Chemical Property of Methionyl-Tyrosine

Chemical Property:

• Melting Point: 260-266 °C
• Boiling Point: 620.3±55.0 °C(Predicted)
• PKA: 3.02±0.10(Predicted)
• PSA: 137.95000
• Density: 1.308±0.06 g/cm3(Predicted)
• LogP: 1.67570
• Storage Temp.: -15°C
• XLogP3: -2
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 8
• Exact Mass: 312.11437830
• Heavy Atom Count: 21
• Complexity: 346

Purity/Quality:

99% ^*data from raw suppliers

Met-Tyr-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CSCCC(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)O)N
• Isomeric SMILES: CSCC[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O)N

Technology Process of Methionyl-Tyrosine

There total 4 articles about Methionyl-Tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Met-OMe (10332-17-9,874219-77-9) + L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → Met-Tyr-OH (13589-04-3)

Guidance literature:

With aminolysin-A; In water; dimethyl sulfoxide; at 50 ℃; for 6h; pH=8; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1039/c0ob00403k

Reference yield:

Cbz-L-Met-L-Tyr-OH (106861-80-7) → Met-Tyr-OH (13589-04-3)

Guidance literature:

With methanol; palladium; Hydrogenation;

Reference yield:

L-tyrosine ethyl ester (949-67-7) → Met-Tyr-OH (13589-04-3)

Guidance literature:

Multi-step reaction with 3 steps

1: ethyl acetate

2: aqueous methanol. NaOH-solution

3: palladium; methanol / Hydrogenation

With methanol; sodium hydroxide; palladium; ethyl acetate;

upstream raw materials:

Cbz-L-Met-L-Tyr-OH

L-tyrosine ethyl ester

Met-OMe

L-tyrosine

Refernces