N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-2,5-dimethoxyphenyl]-2-bromo-N-butyl-5-methoxybenzamide

Base Information

Chemical Name:N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-2,5-dimethoxyphenyl]-2-bromo-N-butyl-5-methoxybenzamide
CAS No.:1307741-53-2
Molecular Formula:C₃₀H₃₀BrF₆NO₅
Molecular Weight:678.466
Hs Code.:

Synonyms:N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-2,5-dimethoxyphenyl]-2-bromo-N-butyl-5-methoxybenzamide

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Chemical Property of N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-2,5-dimethoxyphenyl]-2-bromo-N-butyl-5-methoxybenzamide

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Technology Process of N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-2,5-dimethoxyphenyl]-2-bromo-N-butyl-5-methoxybenzamide

There total 3 articles about N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-2,5-dimethoxyphenyl]-2-bromo-N-butyl-5-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1307741-45-2
2-bromo-N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,5-dimethoxyphenyl]-5-methoxybenzamide

: 100-39-0
benzyl bromide

: 1307741-53-2
N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-2,5-dimethoxyphenyl]-2-bromo-N-butyl-5-methoxybenzamide

Guidance literature:: 2-bromo-N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,5-dimethoxyphenyl]-5-methoxybenzamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.03.002

Reference yield:

: 1307741-27-0
2-(4-butylamino-2,5-dimethoxyphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

: 1307741-53-2
N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-2,5-dimethoxyphenyl]-2-bromo-N-butyl-5-methoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: Vilsmeier reagent / dichloromethane / 1 h / 20 °C / Inert atmosphere

1.2: 3 h / 0 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 3 h / 0 °C / Inert atmosphere

With Vilsmeier reagent; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.002

Reference yield:

: 356537-67-2
2,5-dimethoxy-N-butylaniline

: 1307741-53-2
N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-2,5-dimethoxyphenyl]-2-bromo-N-butyl-5-methoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / toluene / 10 h / 120 °C

2.1: Vilsmeier reagent / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.2: 3 h / 0 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere

3.2: 3 h / 0 °C / Inert atmosphere

With Vilsmeier reagent; sodium hydride; toluene-4-sulfonic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.03.002