9-α-hydroxy-10-α-acetyl-2'(R,S)-hydroxy-3'(S)-isobutyl-3'-(N-t-butoxycarbonyl)-taxane

Base Information

Chemical Name:9-α-hydroxy-10-α-acetyl-2'(R,S)-hydroxy-3'(S)-isobutyl-3'-(N-t-butoxycarbonyl)-taxane
CAS No.:849213-25-8
Molecular Formula:C₄₃H₆₁NO₁₅
Molecular Weight:831.955
Hs Code.:

Synonyms:9-α-hydroxy-10-α-acetyl-2'(R,S)-hydroxy-3'(S)-isobutyl-3'-(N-t-butoxycarbonyl)-taxane

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Chemical Property of 9-α-hydroxy-10-α-acetyl-2'(R,S)-hydroxy-3'(S)-isobutyl-3'-(N-t-butoxycarbonyl)-taxane

Chemical Property:

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Technology Process of 9-α-hydroxy-10-α-acetyl-2'(R,S)-hydroxy-3'(S)-isobutyl-3'-(N-t-butoxycarbonyl)-taxane

There total 12 articles about 9-α-hydroxy-10-α-acetyl-2'(R,S)-hydroxy-3'(S)-isobutyl-3'-(N-t-butoxycarbonyl)-taxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 849342-14-9
C₆₂H₇₁NO₁₇

: 24424-99-5
di-tert-butyl dicarbonate

: 849213-25-8
9-α-hydroxy-10-α-acetyl-2'(R,S)-hydroxy-3'(S)-isobutyl-3'-(N-t-butoxycarbonyl)-taxane

Guidance literature:: C₆₂H₇₁NO₁₇; With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; water; for 31h;

di-tert-butyl dicarbonate; With triethylamine; In tetrahydrofuran; for 21h;

Reference yield:

: 849213-24-7
C₅₅H₈₉NO₁₅Si₂

: 849213-25-8
9-α-hydroxy-10-α-acetyl-2'(R,S)-hydroxy-3'(S)-isobutyl-3'-(N-t-butoxycarbonyl)-taxane

Guidance literature:: With camphor-10-sulfonic acid; In methanol; dichloromethane; at 20 ℃; for 4h; Product distribution / selectivity;

Reference yield:

: 194864-02-3
C-7,C-10-dibenzyloxycarbonyl-10-deacetyl baccatin III

: 849213-25-8
9-α-hydroxy-10-α-acetyl-2'(R,S)-hydroxy-3'(S)-isobutyl-3'-(N-t-butoxycarbonyl)-taxane

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap; dicyclohexyl-carbodiimide / toluene / 51 °C

2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / tetrahydrofuran; water / 66 h

3.1: triethylamine / dmap / dichloromethane / 6 h

4.1: 4-methylmorpholine N-oxide; sodium sulfate / dichloromethane / 1 h

4.2: 17.75 h / Molecular sieve

5.1: sodium tetrahydroborate / methanol; ethanol / 3 h / 0 °C

6.1: triethylamine / dmap / dichloromethane / 19 h

7.1: camphor-10-sulfonic acid / methanol; dichloromethane / 4 h / 20 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; camphor-10-sulfonic acid; hydrogen; 4-methylmorpholine N-oxide; sodium sulfate; triethylamine; dicyclohexyl-carbodiimide; dmap; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;