Technology Process of 9-α-hydroxy-10-α-acetyl-2'(R,S)-hydroxy-3'(S)-isobutyl-3'-(N-t-butoxycarbonyl)-taxane
There total 12 articles about 9-α-hydroxy-10-α-acetyl-2'(R,S)-hydroxy-3'(S)-isobutyl-3'-(N-t-butoxycarbonyl)-taxane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C62H71NO17;
With
hydrogenchloride; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; water;
for 31h;
di-tert-butyl dicarbonate;
With
triethylamine;
In
tetrahydrofuran;
for 21h;
- Guidance literature:
-
With
camphor-10-sulfonic acid;
In
methanol; dichloromethane;
at 20 ℃;
for 4h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: dmap; dicyclohexyl-carbodiimide / toluene / 51 °C
2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / tetrahydrofuran; water / 66 h
3.1: triethylamine / dmap / dichloromethane / 6 h
4.1: 4-methylmorpholine N-oxide; sodium sulfate / dichloromethane / 1 h
4.2: 17.75 h / Molecular sieve
5.1: sodium tetrahydroborate / methanol; ethanol / 3 h / 0 °C
6.1: triethylamine / dmap / dichloromethane / 19 h
7.1: camphor-10-sulfonic acid / methanol; dichloromethane / 4 h / 20 °C
With
hydrogenchloride; dmap; sodium tetrahydroborate; camphor-10-sulfonic acid; hydrogen; 4-methylmorpholine N-oxide; sodium sulfate; triethylamine; dicyclohexyl-carbodiimide;
dmap; palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;
