Technology Process of 6-cyano-1,2-dihydro-2-oxo-1-phenylpyridine-3-carboxylic acid ethyl ester
There total 11 articles about 6-cyano-1,2-dihydro-2-oxo-1-phenylpyridine-3-carboxylic acid ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 20 - 50 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Heating / reflux
2: triethylamine / acetonitrile / 2 h / 0 - 20 °C
3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 5 h / Heating / reflux; Irradiation
4: water; sodium hydrogencarbonate / 1,4-dioxane / 3 h / 60 °C
5: ammonium formate / palladium 10% on activated carbon / ethyl acetate / 8 h / 65 °C
6: Dess-Martin periodane / dichloromethane / 4 h / 20 °C
7: hydroxylamine hydrochloride; potassium acetate / ethanol / 8 h / 50 °C
8: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 20 - 50 °C
With
dmap; N-Bromosuccinimide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; water; ammonium formate; potassium acetate; sodium hydrogencarbonate; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
palladium 10% on activated carbon; N,N-dimethyl-formamide;
In
1,4-dioxane; tetrachloromethane; ethanol; dichloromethane; ethyl acetate; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 5 h / Heating / reflux; Irradiation
2: water; sodium hydrogencarbonate / 1,4-dioxane / 3 h / 60 °C
3: ammonium formate / palladium 10% on activated carbon / ethyl acetate / 8 h / 65 °C
4: Dess-Martin periodane / dichloromethane / 4 h / 20 °C
5: hydroxylamine hydrochloride; potassium acetate / ethanol / 8 h / 50 °C
6: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 20 - 50 °C
With
dmap; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; water; ammonium formate; potassium acetate; sodium hydrogencarbonate; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium 10% on activated carbon;
In
1,4-dioxane; tetrachloromethane; ethanol; dichloromethane; ethyl acetate;
