1,2-dihydro-6-(hydroxyimino)methyl-2-oxo-1-phenylpyridine-3-carboxylic acid ethyl ester

Base Information

Chemical Name:1,2-dihydro-6-(hydroxyimino)methyl-2-oxo-1-phenylpyridine-3-carboxylic acid ethyl ester
CAS No.:945898-90-8
Molecular Formula:C₁₅H₁₄N₂O₄
Molecular Weight:286.287
Hs Code.:

Synonyms:1,2-dihydro-6-(hydroxyimino)methyl-2-oxo-1-phenylpyridine-3-carboxylic acid ethyl ester

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Chemical Property of 1,2-dihydro-6-(hydroxyimino)methyl-2-oxo-1-phenylpyridine-3-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 1,2-dihydro-6-(hydroxyimino)methyl-2-oxo-1-phenylpyridine-3-carboxylic acid ethyl ester

There total 9 articles about 1,2-dihydro-6-(hydroxyimino)methyl-2-oxo-1-phenylpyridine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-formyl-1-phenyl-1,2-dihydro-2-oxopyridine-3-carboxylic acid ethyl ester

: 945898-90-8
1,2-dihydro-6-(hydroxyimino)methyl-2-oxo-1-phenylpyridine-3-carboxylic acid ethyl ester

Guidance literature:: With hydroxylamine hydrochloride; potassium acetate; In ethanol; at 50 ℃; for 8h;

Reference yield:

: 694475-70-2
6-methyl-2-oxo-1-phenyl-1,2-dihydro-3-pyridinecarboxylic acid

: 945898-90-8
1,2-dihydro-6-(hydroxyimino)methyl-2-oxo-1-phenylpyridine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Heating / reflux

2: triethylamine / acetonitrile / 2 h / 0 - 20 °C

3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 5 h / Heating / reflux; Irradiation

4: water; sodium hydrogencarbonate / 1,4-dioxane / 3 h / 60 °C

5: ammonium formate / palladium 10% on activated carbon / ethyl acetate / 8 h / 65 °C

6: Dess-Martin periodane / dichloromethane / 4 h / 20 °C

7: hydroxylamine hydrochloride; potassium acetate / ethanol / 8 h / 50 °C

With N-Bromosuccinimide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; water; ammonium formate; potassium acetate; sodium hydrogencarbonate; Dess-Martin periodane; triethylamine; palladium 10% on activated carbon; N,N-dimethyl-formamide; In 1,4-dioxane; tetrachloromethane; ethanol; dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

: 945898-86-2
1,2-dihydro-6-methyl-2-oxo-1-phenylpyridine-3-carboxylic acid ethyl ester

: 945898-90-8
1,2-dihydro-6-(hydroxyimino)methyl-2-oxo-1-phenylpyridine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 5 h / Heating / reflux; Irradiation

2: water; sodium hydrogencarbonate / 1,4-dioxane / 3 h / 60 °C

3: ammonium formate / palladium 10% on activated carbon / ethyl acetate / 8 h / 65 °C

4: Dess-Martin periodane / dichloromethane / 4 h / 20 °C

5: hydroxylamine hydrochloride; potassium acetate / ethanol / 8 h / 50 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; water; ammonium formate; potassium acetate; sodium hydrogencarbonate; Dess-Martin periodane; palladium 10% on activated carbon; In 1,4-dioxane; tetrachloromethane; ethanol; dichloromethane; ethyl acetate;