Technology Process of C8H8F2O2
There total 4 articles about C8H8F2O2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,4-difluorobenzaldehyde;
With
potassium osmate(VI) dihydrate; hydroquinine 1,4-phthalazinediyl diether; 4-methylmorpholine N-oxide;
In
water; tert-butyl alcohol;
at 20 ℃;
for 21h;
With
sodium sulfite;
In
water; toluene; tert-butyl alcohol;
for 2h;
With
sulfuric acid; sodium sulfate;
In
water; toluene;
- Guidance literature:
-
With
wild type epoxide hydrolase from Vigna radiata (VrEH2);
In
aq. phosphate buffer; dimethyl sulfoxide;
at 30 ℃;
pH=7;
Reagent/catalyst;
enantioselective reaction;
Enzymatic reaction;
DOI:10.1002/adsc.202000898
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran / 0 - 20 °C
1.2: 0 - 20 °C
2.1: potassium osmate(VI) dihydrate; hydroquinine 1,4-phthalazinediyl diether; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 21 h / 20 °C
2.2: 2 h
With
potassium osmate(VI) dihydrate; hydroquinine 1,4-phthalazinediyl diether; potassium hexamethylsilazane; 4-methylmorpholine N-oxide;
In
tetrahydrofuran; water; tert-butyl alcohol;