1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-<((methoxyethoxy)methyl)oxy>-5-iodopentane

Base Information

Chemical Name:1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-<((methoxyethoxy)methyl)oxy>-5-iodopentane
CAS No.:144609-51-8
Molecular Formula:C₂₃H₄₁IO₄Si
Molecular Weight:536.566
Hs Code.:

Synonyms:1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-<((methoxyethoxy)methyl)oxy>-5-iodopentane

Suppliers and Price of 1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-<((methoxyethoxy)methyl)oxy>-5-iodopentane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-<((methoxyethoxy)methyl)oxy>-5-iodopentane

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Technology Process of 1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-<((methoxyethoxy)methyl)oxy>-5-iodopentane

There total 6 articles about 1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-<((methoxyethoxy)methyl)oxy>-5-iodopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Methanesulfonic acid 5-[4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-phenyl]-5-(2-methoxy-ethoxymethoxy)-pentyl ester

: 144609-51-8
1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-<((methoxyethoxy)methyl)oxy>-5-iodopentane

Guidance literature:: With sodium iodide; at 20 ℃; for 5h; Yield given;
DOI:10.1021/ja00051a009

Reference yield:

: 2100-17-6
4-pentenal

: 144609-51-8
1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-<((methoxyethoxy)methyl)oxy>-5-iodopentane

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) t-BuLi / 1.) pentane, THF, -78 deg C, 75 min, 2.) from -78 deg C to RT, 1 h

2: 93 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 4 h / 24 °C

3: 1.) borane-tetrahydrofuran, 2.) aq. NaOH, aq. H₂O₂ / 1.) THF, from 0 deg C to RT, 4.7 h, 2.) 0 deg C, 1 h

4: triethylamine / CH₂Cl₂ / 3 h / 0 °C

5: sodium iodide-triacetone / 5 h / 20 °C

With sodium hydroxide; borane-THF; dihydrogen peroxide; tert.-butyl lithium; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; In dichloromethane;
DOI:10.1021/ja00051a009

Reference yield:

: 139229-99-5
1-Bromo-4<(tert-butyldimethylsilyl)oxy>-3,5-dimethylbenzene

: 144609-51-8
1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-<((methoxyethoxy)methyl)oxy>-5-iodopentane

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) t-BuLi / 1.) pentane, THF, -78 deg C, 75 min, 2.) from -78 deg C to RT, 1 h

2: 93 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 4 h / 24 °C

3: 1.) borane-tetrahydrofuran, 2.) aq. NaOH, aq. H₂O₂ / 1.) THF, from 0 deg C to RT, 4.7 h, 2.) 0 deg C, 1 h

4: triethylamine / CH₂Cl₂ / 3 h / 0 °C

5: sodium iodide-triacetone / 5 h / 20 °C

With sodium hydroxide; borane-THF; dihydrogen peroxide; tert.-butyl lithium; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; In dichloromethane;
DOI:10.1021/ja00051a009