4-hydroxy-4-(4-methoxyphenyl)-N-methyl-N'-phenyl-N-tosylbut-2-ynimidamide

Base Information

Chemical Name:4-hydroxy-4-(4-methoxyphenyl)-N-methyl-N'-phenyl-N-tosylbut-2-ynimidamide
CAS No.:1562381-61-6
Molecular Formula:C₂₅H₂₄N₂O₄S
Molecular Weight:448.543
Hs Code.:

Synonyms:4-hydroxy-4-(4-methoxyphenyl)-N-methyl-N'-phenyl-N-tosylbut-2-ynimidamide

Suppliers and Price of 4-hydroxy-4-(4-methoxyphenyl)-N-methyl-N'-phenyl-N-tosylbut-2-ynimidamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-hydroxy-4-(4-methoxyphenyl)-N-methyl-N'-phenyl-N-tosylbut-2-ynimidamide

Chemical Property:

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Technology Process of 4-hydroxy-4-(4-methoxyphenyl)-N-methyl-N'-phenyl-N-tosylbut-2-ynimidamide

There total 15 articles about 4-hydroxy-4-(4-methoxyphenyl)-N-methyl-N'-phenyl-N-tosylbut-2-ynimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: N-methyl-N'-phenyl-N-tosylpropiolimidamide

: 123-11-5
4-methoxy-benzaldehyde

: 1562381-61-6
4-hydroxy-4-(4-methoxyphenyl)-N-methyl-N'-phenyl-N-tosylbut-2-ynimidamide

Guidance literature:: N-methyl-N'-phenyl-N-tosylpropiolimidamide; 4-methoxy-benzaldehyde; With trimethylsilyl trifluoromethanesulfonate; diisopropylamine; zinc dibromide; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere; Sealed tube;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; at 28 ℃; for 0.5h; Inert atmosphere; Sealed tube;
DOI:10.1021/ja412634w

Reference yield:

: 640-61-9
N-methyl-p-toluenesulfonylamide

: 1562381-61-6
4-hydroxy-4-(4-methoxyphenyl)-N-methyl-N'-phenyl-N-tosylbut-2-ynimidamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,10-Phenanthroline; potassium carbonate; copper(ll) sulfate pentahydrate / toluene / 80 °C / Inert atmosphere; Sealed tube

2.1: zinc trifluoromethanesulfonate / dichloromethane / 2.5 h / 50 °C / Inert atmosphere

3.1: diisopropylamine; zinc dibromide; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 3 h / 20 °C / Inert atmosphere; Sealed tube

3.2: 0.5 h / 28 °C / Inert atmosphere; Sealed tube

With 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; trimethylsilyl trifluoromethanesulfonate; zinc trifluoromethanesulfonate; potassium carbonate; diisopropylamine; zinc dibromide; In dichloromethane; toluene;
DOI:10.1021/ja412634w

Reference yield:

: (4-(2-iodophenyl)but-3-en-1-yn-1-yl)-N,4-dimethylbenzenesulfonamide

: 1562381-61-6
4-hydroxy-4-(4-methoxyphenyl)-N-methyl-N'-phenyl-N-tosylbut-2-ynimidamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: silver(I) acetate / dichloromethane / 0.5 h / 50 °C / Inert atmosphere

2.1: diisopropylamine; zinc dibromide; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 3 h / 20 °C / Inert atmosphere; Sealed tube

2.2: 0.5 h / 28 °C / Inert atmosphere; Sealed tube

With trimethylsilyl trifluoromethanesulfonate; silver(I) acetate; diisopropylamine; zinc dibromide; In dichloromethane;
DOI:10.1021/ja412634w