N-methyl-2-(1H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-4-biphenylsulfonamide

Base Information

Chemical Name:N-methyl-2-(1H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-4-biphenylsulfonamide
CAS No.:1351092-32-4
Molecular Formula:C₁₉H₁₇N₅O₂S
Molecular Weight:379.442
Hs Code.:

Synonyms:N-methyl-2-(1H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-4-biphenylsulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-methyl-2-(1H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-4-biphenylsulfonamide

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Technology Process of N-methyl-2-(1H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-4-biphenylsulfonamide

There total 4 articles about N-methyl-2-(1H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-4-biphenylsulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1351092-89-1
4-chloro-N-methyl-3-(1H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzenesulfonamide

: 98-80-6
phenylboronic acid

: 1351092-32-4
N-methyl-2-(1H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-4-biphenylsulfonamide

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 140 ℃; for 4h;

Reference yield:

: 97-08-5
3-nitro-4-chlorosulfonyl chloride

: 1351092-32-4
N-methyl-2-(1H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-4-biphenylsulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 1 h / -40 - 20 °C

2: ammonium chloride / iron / ethanol; water / 4 h / 90 °C

3: silver trifluoromethanesulfonate / 1-methyl-pyrrolidin-2-one / 60 h / 165 °C

4: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 140 °C

With silver trifluoromethanesulfonate; potassium carbonate; ammonium chloride; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iron; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; water;

Reference yield:

: 137-48-4
2-chloro-5-(N-methylsulfamoyl)-nitrobenzene

: 1351092-32-4
N-methyl-2-(1H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-4-biphenylsulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium chloride / iron / ethanol; water / 4 h / 90 °C

2: silver trifluoromethanesulfonate / 1-methyl-pyrrolidin-2-one / 60 h / 165 °C

3: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 140 °C

With silver trifluoromethanesulfonate; potassium carbonate; ammonium chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iron; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; water;